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The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin
Joint Authors
Ibrahim, Razaw O.
Omer, Shirwan H.
Fattah, Chro N.
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Kisspeptin is a neuropeptide that upregulates gonadotropin-releasing hormone (GnRH) secretion.
It is an essential element for the luteinizing hormone (LH) surge and ovulation.
Women with polycystic ovary syndrome (PCOS) expose alteration in both GnRH and LH secretion levels.
Objective.
This paper aims to evaluate serum kisspeptin levels in healthy and polycystic ovarian syndrome women.
Furthermore, it investigates the effect of obesity and age on circulating kisspeptin levels in both normal and PCOS women.
Moreover, it points out the correlation between kisspeptin and other hormonal parameters.
Methods and Patients.
One hundred women (60 are with PCOS and 40 are normal) were enrolled in the study.
Five milliliter samples of blood from all the patients and control women were obtained twice during the menstrual cycle.
All the study samples were classified depending on the age factor for several subgroups.
Results.
Kisspeptin levels were higher in PCOS patients than those in the normal group.
Kisspeptin correlated with serum free testosterone level (r=0.26).
In healthy women, preovulatory kisspeptin levels were higher than follicular kisspeptin levels (P<0.05), while this difference was insignificant in PCOS patients.
The variation in serum kisspeptin levels between overweight/obese and normal-weight women was insignificant.
In normal women, serum kisspeptin levels were higher in women >35 years than those <24 years at (P=0.03).
Conclusion.
The serum kisspeptin level is higher in PCOS women.
Its levels fluctuate during the menstrual cycle, but these fluctuations are disturbed in PCOS women.
The effect of BMI on serum kisspeptin levels is insignificant, and kisspeptin serum levels increase with age.
American Psychological Association (APA)
Ibrahim, Razaw O.& Omer, Shirwan H.& Fattah, Chro N.. 2020. The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170402
Modern Language Association (MLA)
Ibrahim, Razaw O.…[et al.]. The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170402
American Medical Association (AMA)
Ibrahim, Razaw O.& Omer, Shirwan H.& Fattah, Chro N.. The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170402