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A Significant Association of Upper Limb Muscle Strength with Thyroid Function in Overweight and Obese Population: A Study of the Sixth Korea National Health and Nutrition Examination Survey (KNHANES 2014-2015)
Joint Authors
Lim, Dong-Jun
Lee, Jung Min
Kang, Moo Il
Lee, Jeongmin
Jo, Kwanhoon
Ha, Jeonghoon
Chang, Sang-Ah
Kim, Min-Hee
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
As skeletal muscle is one of main targets of thyroid hormone signalling, an association of thyroid function and muscle strength could be expected.
The aim of study is to evaluate the association of free thyroxine (FT4) and thyrotropin (TSH) with upper limb muscle strength, measured by hand grip strength, in subjects with normal FT4 from national representative data.
The study utilized the sixth edition of the Korea National Health and Nutrition Examination Survey.
After exclusion of subjects with FT4 level out of normal range, a history of thyroid disease or cerebral disease, restricted activity, and incomplete data, a total of 3503 were recruited (age range 19–80 years, 51% male).
FT4 positively correlated with upper limb muscle strength (β coefficient = −12.84, p<0.001), while TSH did negatively (β coefficient = −0.37, p=0.002).
After adjusting for confounding factors, statistical significance disappeared.
However, among subjects with BMI above 23 kg/m2, a negative correlation of TSH with upper limb muscle strength was found in a younger age group (19–39 years old) (β coefficient = −0.56, p=0.021), while FT4 positively correlated with upper limb muscle strength (β coefficient = 3.24, p=0.019) in an older group (above 40 years old).
In overweight and obese subjects, a significant association of thyroid function with upper limb muscle strength was observed in nation-wide representative data.
High TSH in a younger group and low FT4 in an older group could be risk factors for decreased upper limb muscle strength in obese population.
American Psychological Association (APA)
Lee, Jeongmin& Jo, Kwanhoon& Ha, Jeonghoon& Lim, Dong-Jun& Lee, Jung Min& Chang, Sang-Ah…[et al.]. 2020. A Significant Association of Upper Limb Muscle Strength with Thyroid Function in Overweight and Obese Population: A Study of the Sixth Korea National Health and Nutrition Examination Survey (KNHANES 2014-2015). International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170456
Modern Language Association (MLA)
Lee, Jeongmin…[et al.]. A Significant Association of Upper Limb Muscle Strength with Thyroid Function in Overweight and Obese Population: A Study of the Sixth Korea National Health and Nutrition Examination Survey (KNHANES 2014-2015). International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170456
American Medical Association (AMA)
Lee, Jeongmin& Jo, Kwanhoon& Ha, Jeonghoon& Lim, Dong-Jun& Lee, Jung Min& Chang, Sang-Ah…[et al.]. A Significant Association of Upper Limb Muscle Strength with Thyroid Function in Overweight and Obese Population: A Study of the Sixth Korea National Health and Nutrition Examination Survey (KNHANES 2014-2015). International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170456