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Antibacterial Activity and Cytotoxic Effect of Pelargonium peltatum (Geranium) against Streptococcus mutans and Streptococcus sanguinis
Joint Authors
Aguilar-Luis, Miguel Angel
Mazulis, Fernando
del Valle-Mendoza, Juana
Caballero-García, Stefany
Coronado-López, Samantha
Source
International Journal of Dentistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To evaluate the in vitro antibacterial and cytotoxic properties of the methanolic extract of Pelargonium peltatum (geranium) against Streptococcus mutans (ATCC 25175) and Streptococcus sanguinis (ATCC 10556).
Methods.
Three extracts of P.
peltatum were prepared using the leaf, stem, and root.
Nine independent assays were prepared for each type of extract with chlorhexidine at 0.12% as the positive control.
The agar diffusion method was performed to determine the antibacterial properties of each extract.
The minimum inhibitory concentration (MIC) was determined using the microdilution method, and the cytotoxicity was analyzed by means of the MTT reduction test using a MDCK cell line.
Results.
The root extract had the highest antibacterial effect with a mean result of (27.68 ± 0.97) mm and (30.80 ± 0.55) mm against S.
mutans and S.
sanguinis, respectively.
The minimum inhibitory concentration for the leaf and root extracts was 250 mg/mL for S.
mutans and 125 mg/mL for S.
sanguinis.
Cytotoxicity assays showed that both extracts had a low cytotoxicity at high concentrations.
The cellular viability was highest for the root extract at 95.3% followed by the stem extract at 80.8% and finally the leaf extract with 75.4%.
Conclusions.
These findings show the antibacterial properties of the methanolic extracts of P.
pelargonium against S.
mutans and S.
sanguinis.
These extracts were not cytotoxic at high concentrations.
American Psychological Association (APA)
Coronado-López, Samantha& Caballero-García, Stefany& Aguilar-Luis, Miguel Angel& Mazulis, Fernando& del Valle-Mendoza, Juana. 2018. Antibacterial Activity and Cytotoxic Effect of Pelargonium peltatum (Geranium) against Streptococcus mutans and Streptococcus sanguinis. International Journal of Dentistry،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1170459
Modern Language Association (MLA)
Coronado-López, Samantha…[et al.]. Antibacterial Activity and Cytotoxic Effect of Pelargonium peltatum (Geranium) against Streptococcus mutans and Streptococcus sanguinis. International Journal of Dentistry No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1170459
American Medical Association (AMA)
Coronado-López, Samantha& Caballero-García, Stefany& Aguilar-Luis, Miguel Angel& Mazulis, Fernando& del Valle-Mendoza, Juana. Antibacterial Activity and Cytotoxic Effect of Pelargonium peltatum (Geranium) against Streptococcus mutans and Streptococcus sanguinis. International Journal of Dentistry. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1170459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170459