Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus
Joint Authors
Miao, Zhirong
Wu, Honghua
Ren, Liu
Bu, Nan
Jiang, Lili
Zhang, Junqing
Guo, Xiaohui
Yang, Huixia
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
The objective of the present study was to explore the long-term postpartum glucose metabolism in women with previous GDM, and study the mechanism of hyperglycemia from gestation to postpartum by investigating the postpartum insulin resistance and insulin secretion.
Methods.
A total of 321 females with previous GDM were followed up once during 1- to 6-years postpartum.
Characteristics during pregnancy, perinatal period, and postpartum were compared between postpartum NGT and hyperglycemic women.
HOMA-IR and HOMA-β were used to assess insulin resistance and insulin secretion levels with different glucose statuses.
Results.
The prevalence of postpartum hyperglycemia had a fluctuant increase from 25.9% at 1 year, to 53.7% at 5 year.
75 g OGTT 2 hPG during pregnancy was an independent predictor of postpartum hyperglycemia with an OR of 2.15 (95% CI 1.245, 3.722) (P=0.006).
After ROC analysis, the best equilibrium between sensitivity (70.3%) and specificity (60.4%) for 2 hPG was 9.03 mmol/L.
HOMA-IR was increased in postpartum normal glucose tolerance (NGT), prediabetes, and T2DM (1.64 vs.
2.14 vs.
4.27, P<0.001), while HOMA-β was decreased (1.19 vs.
1.11 vs.
0.71, P=0.011).
In pairwise comparison, except for HOMA-IR between prediabetes and T2DM, and HOMA-β between NGT and prediabetes, other differences showed significance.
Conclusions.
75 g OGTT 2h PG during pregnancy higher than 9.03 mmol/L is regarded as an independent risk factor of postpartum hyperglycemia.
Insulin resistance with insufficient insulin secretion compensation is still common phenomenon during long-term postpartum.
Women with heavier insulin resistance in the postpartum period are more likely develop prediabetes, while decreased β-cell function contributes more to T2DM development.
American Psychological Association (APA)
Miao, Zhirong& Wu, Honghua& Ren, Liu& Bu, Nan& Jiang, Lili& Yang, Huixia…[et al.]. 2020. Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170474
Modern Language Association (MLA)
Miao, Zhirong…[et al.]. Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus. International Journal of Endocrinology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1170474
American Medical Association (AMA)
Miao, Zhirong& Wu, Honghua& Ren, Liu& Bu, Nan& Jiang, Lili& Yang, Huixia…[et al.]. Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1170474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170474