Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis
Joint Authors
Beretvas, S. Natasha
Freeland-Graves, Jeanne H.
Sachdev, Prageet K.
Sanjeevi, Namrata
Source
International Journal of Dentistry
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Oral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa.
Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent.
The objective of this research is to perform a meta-analysis to summarize studies that report zinc (Zn), copper (Cu), and iron (Fe) in patients, with and without OSF.
A literature search of Embase, PubMed, Cochrane Library, and Web of Science electronic databases was conducted for studies up to January 2017.
A total of 34 reports met the inclusion criteria.
The standardized mean difference was utilized as the effect size.
The robust variance estimation method was chosen to handle dependency of multiple related outcomes in meta-analysis.
There was a significant increase in the levels of Cu (effect size = 1.17, p value < 0.05, 95% confidence interval (CI): 0.164–2.171) and a significant decrease in levels of Zn (effect size = −1.95, p value < 0.05, 95% CI: −3.524 to −0.367) and Fe (effect size = −2.77, p value < 0.01, 95% CI: −4.126 to −1.406) in OSF patients.
The estimation of Zn, Cu, and Fe levels may serve as additional biomarkers in the diagnosis and prognosis of OSF along with the clinical features.
American Psychological Association (APA)
Sachdev, Prageet K.& Freeland-Graves, Jeanne H.& Beretvas, S. Natasha& Sanjeevi, Namrata. 2018. Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis. International Journal of Dentistry،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1170476
Modern Language Association (MLA)
Sachdev, Prageet K.…[et al.]. Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis. International Journal of Dentistry No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1170476
American Medical Association (AMA)
Sachdev, Prageet K.& Freeland-Graves, Jeanne H.& Beretvas, S. Natasha& Sanjeevi, Namrata. Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis. International Journal of Dentistry. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1170476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170476