Could Serum TSH Levels Predict Malignancy in Euthyroid Patients Affected by Thyroid Nodules with Indeterminate Cytology?
Joint Authors
Casella, Claudio
Cappelli, Carlo
Pirola, Ilenia
Gandossi, Elena
Castellano, Maurizio
Rotondi, Mario
Chiovato, Luca
Ferlin, Alberto
Marini, Fiorella
Lombardi, Davide
Agosti, Barbara
Saullo, Maura
Di Lodovico, Elena
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Serum TSH levels in the upper-normal range were reported to be associated with increased risk of thyroid malignancy.
However, measurement of TSH levels is currently not recommended for assessing the risk of malignancy in patients with newly diagnosed thyroid nodules.
Objective.
To evaluate a possible relationship between the serum levels of TSH and the histological outcome of patients undergoing thyroidectomy for thyroid nodules with indeterminate cytology.
Materials and Methods.
We collected the clinical data of all patients who had performed ultrasound-guided FNA of thyroid nodules with cytological diagnosis of indeterminate lesions (TIR3A and TIR3B) and serum TSH levels within the normal range.
All patients had been submitted to thyroid surgery (hemi or thyroidectomy, as appropriate), and histological diagnosis had been performed.
Results.
A histological diagnosis of thyroid malignancy was rendered in 74/378 (19.6%) nodules.
Patients with histologically proven thyroid malignancy were characterized by higher serum levels of TSH as compared to patients with histologically proven benign nodules (3.03 ± 1.16 vs.
2.37 ± 1.19 mIU/L, p<0.001).
To further analyze the role of serum TSH in predicting thyroid cancer, patients were stratified in 4 groups according to quartiles of TSH concentrations.
The prevalence of malignancy was 12.2% for the first quartile and 50.0% for the last quartile.
ROC curve analysis identified that a serum TSH level of ≥2.7 mIU/L predicted thyroid malignancy with a sensitivity of 61% and a specificity of 65%.
Conclusions.
TSH levels in the upper-normal range are associated with an increased risk of thyroid malignancy in patients affected by thyroid nodules with indeterminate cytology at FNA.
The measurement of serum TSH levels represents an easily performed additional tool for decision-making in patients with indeterminate cytological findings.
American Psychological Association (APA)
Cappelli, Carlo& Pirola, Ilenia& Gandossi, Elena& Rotondi, Mario& Lombardi, Davide& Casella, Claudio…[et al.]. 2020. Could Serum TSH Levels Predict Malignancy in Euthyroid Patients Affected by Thyroid Nodules with Indeterminate Cytology?. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170477
Modern Language Association (MLA)
Cappelli, Carlo…[et al.]. Could Serum TSH Levels Predict Malignancy in Euthyroid Patients Affected by Thyroid Nodules with Indeterminate Cytology?. International Journal of Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1170477
American Medical Association (AMA)
Cappelli, Carlo& Pirola, Ilenia& Gandossi, Elena& Rotondi, Mario& Lombardi, Davide& Casella, Claudio…[et al.]. Could Serum TSH Levels Predict Malignancy in Euthyroid Patients Affected by Thyroid Nodules with Indeterminate Cytology?. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170477