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Real-World Data for Lenvatinib in Radioiodine-Refractory Differentiated Thyroid Cancer (RELEVANT): A Retrospective Multicentric Analysis of Clinical Practice in Austria
Joint Authors
Rendl, G.
Sipos, B.
Becherer, A.
Sorko, S.
Trummer, C.
Raderer, M.
Hitzl, W.
Ardelt, M.
Gallowitsch, H. J.
Pirich, C.
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Lenvatinib has proven efficacy in progressive, radioiodine- (RAI-) refractory thyroid cancer (TC).
Dose reductions are commonly performed due to decreased tolerability and adverse effects.
This retrospective multicenter study analyzed overall survival (OS) and progression-free survival (PFS) and tolerability in the Austrian patient population treated with lenvatinib.
Methods.
Clinical data of 43 patients (25 males and 18 females) with a median age of 70 years (range: 39–91 years) and RAI-refractory TC with metastases to the lymph nodes (74%), lungs (86%), bone (35%), liver (16%), and brain (12%) were analyzed.
The mean duration of treatment with lenvatinib was 26.6 ± 15.4 months with dosage reductions required in 39 patients (91%).
Results.
PFS after 24 months was 71% (95% CI: 56–87), and overall survival (OS) was 74% (95% CI: 60–88), respectively.
OS was significantly shorter (p=0.048) in patients with a daily maintenance dosage ≤ 10 mg (63%) (95% CI: 39–86) as compared to patients on ≥ 14 mg lenvatinib (82%) (95% CI: 66–98) daily.
Dose reduction was noted in 39 patients (91%).
Grade ≥3 toxicities (hypertension, diarrhea, weight loss, and palmar-plantar erythrodysesthesia syndrome) were most common leading to discontinuation of lenvatinib in 7 patients (16%).
Conclusion.
Lenvatinib showed sustained clinical efficacy in patients with metastatic RAI-refractory TC even with reduced maintenance dosages over years.
The effects were comparable to the registration trial, although patients had a higher median age and, more commonly, dose reductions.
American Psychological Association (APA)
Rendl, G.& Sipos, B.& Becherer, A.& Sorko, S.& Trummer, C.& Raderer, M.…[et al.]. 2020. Real-World Data for Lenvatinib in Radioiodine-Refractory Differentiated Thyroid Cancer (RELEVANT): A Retrospective Multicentric Analysis of Clinical Practice in Austria. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170532
Modern Language Association (MLA)
Rendl, G.…[et al.]. Real-World Data for Lenvatinib in Radioiodine-Refractory Differentiated Thyroid Cancer (RELEVANT): A Retrospective Multicentric Analysis of Clinical Practice in Austria. International Journal of Endocrinology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1170532
American Medical Association (AMA)
Rendl, G.& Sipos, B.& Becherer, A.& Sorko, S.& Trummer, C.& Raderer, M.…[et al.]. Real-World Data for Lenvatinib in Radioiodine-Refractory Differentiated Thyroid Cancer (RELEVANT): A Retrospective Multicentric Analysis of Clinical Practice in Austria. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1170532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170532