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Association between Bone Mineral Density and Severity of Chronic Kidney Disease
Joint Authors
Wang, Xiang-Yang
Zhou, Xiao
Huang, Jin-Feng
Zheng, Xuan-Qi
Sun, Xiao-Lei
Wu, Ai-Min
Li, Yan Michael
Zhang, Xiao-Lei
Liu, Jian
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group.
Methods.
Cross-sectional data from 11050 participants aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) were analyzed.
Specifically, Pearson correlation was applied to analyze the relationship between BMD and estimated glomerular filtration rate (eGFR).
General linear models (GLMs) were adjusted for potential confounders and used to analyze mean BMD, based on CKD and CKD stages.
Results.
FN BMD was positively correlated with the eGFR in the total and male CKD, but not in the female CKD population.
LS BMD was not significantly associated with eGFR.
After controlling for partial correlations, FN T-score was positively correlated with the eGFR in the total at-risk population.
According to FN BMD, OP prevalence was positively associated with CKD stage.
However, according to LS BMD, there was no significant association between OP and CKD stage.
Conclusion.
Our results may explain the higher prevalence of hip fracture, relative to that of the spine, among CKD patients and generate meaningful insights to guide care, prevention, and treatment regimens for CKD patients.
However, the fact that this was a cross-sectional study may limit the possibility of drawing concrete conclusions.
Nevertheless, these findings open up a new frontier for further studies to uncover the higher decrease of FN BMD compared to LS BMD among CKD cases.
American Psychological Association (APA)
Huang, Jin-Feng& Zheng, Xuan-Qi& Sun, Xiao-Lei& Zhou, Xiao& Liu, Jian& Li, Yan Michael…[et al.]. 2020. Association between Bone Mineral Density and Severity of Chronic Kidney Disease. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170542
Modern Language Association (MLA)
Huang, Jin-Feng…[et al.]. Association between Bone Mineral Density and Severity of Chronic Kidney Disease. International Journal of Endocrinology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1170542
American Medical Association (AMA)
Huang, Jin-Feng& Zheng, Xuan-Qi& Sun, Xiao-Lei& Zhou, Xiao& Liu, Jian& Li, Yan Michael…[et al.]. Association between Bone Mineral Density and Severity of Chronic Kidney Disease. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170542