DPP4 Activities Are Associated with OsteopeniaOsteoporosis and Fracture Risk in Newly Diagnosed Type 2 Diabetes
Joint Authors
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Recent studies have shown the beneficial effect of dipeptidyl peptidase-4 (DPP4) inhibitor on bone turnover in diabetes mellitus.
However, little clinical evidence for DPP4 activity in newly diagnosed type 2 diabetes is available.
This study was designed to investigate the relationship between plasma DPP4 activity and osteoporosis/osteopenia and fracture risk in newly diagnosed type 2 diabetes.
Methods.
A total of 147 subjects with newly diagnosed type 2 diabetes were enrolled for this cross-sectional study.
The bone mineral density (BMD) at the lumbar spine (L1-4) and femoral neck (FN) was measured by dual-energy X-ray absorptiometry (DXA).
The 10-year probability of major osteoporotic fracture (MOF) and hip fracture (HF) was assessed by a modified fracture risk algorithm (FRAX) tool.
The plasma DPP4 activity and clinical variables were measured.
Correlation analyses between DPP4 activity and osteoporosis/osteopenia and fracture risk were performed.
Results.
Elevated plasma DPP activities were significantly associated with a higher proportion of osteoporosis/osteopenia (50% for quartile-1, 56.4% for quartile-2, 65.8% for quartile-3 and 72.2% for quartile-4).
With increasing plasma DPP activities, the incidence rate of osteoporosis/osteopenia is gradually increasing (P for the trend between quartiles = 0.04).
Of note, a statistically significant linear correlation was found between plasma DPP4 activities and modified FRAX MOF (r = 0.20, P=0.02).
Moreover, plasma DPP4 activities were also positively related to modified FRAX HF in newly diagnosed type 2 diabetic patients (r = 0.21, P=0.01).
Conclusions.
Elevated plasma DPP4 activity tended to be associated with a higher proportion of osteoporosis/osteopenia and increased the fracture risk in newly diagnosed type 2 diabetes.
American Psychological Association (APA)
Qiu, Min& Zhai, Shuheng& Liu, Da. 2020. DPP4 Activities Are Associated with OsteopeniaOsteoporosis and Fracture Risk in Newly Diagnosed Type 2 Diabetes. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170550
Modern Language Association (MLA)
Qiu, Min…[et al.]. DPP4 Activities Are Associated with OsteopeniaOsteoporosis and Fracture Risk in Newly Diagnosed Type 2 Diabetes. International Journal of Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1170550
American Medical Association (AMA)
Qiu, Min& Zhai, Shuheng& Liu, Da. DPP4 Activities Are Associated with OsteopeniaOsteoporosis and Fracture Risk in Newly Diagnosed Type 2 Diabetes. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170550