Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy
Joint Authors
Bove, A.
Dei Rocini, C.
Di Renzo, R. M.
Farrukh, M.
Palone, G.
Chiarini, S.
Staniscia, T.
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Total thyroidectomy (TT) is recommended in the treatment of malignant and benignant thyroid diseases, and, to date, transient hypocalcemia is the most frequent complication after the procedure.
We prospectively evaluated the role of vitamin D deficiency as a predictor of postoperative hypocalcemia.
Methods.
This is a prospective cohort study which was conducted between January 2016 and April 2019.
A total of 177 consecutive patients (141 (79.7%) women and 36 (20.3%) men) who underwent TT were included in the current study.
Hypocalcemia occurred when serum calcium levels were below 8.0 mg/dL or 1.10 mmol/L.
Patients were divided into two groups (Group 1, normocalcemic; Group 2, hypocalcemic) and were assessed taking into consideration preoperative serum 25-hydroxy vitamin D (25-OHD) levels, preoperative serum calcium levels, thyroid hormone levels, sex, body mass index (BMI), and smoking habits.
Vitamin D deficiency was defined as 25-OHD levels <25 ng/mL.
Results.
The incidence of postoperative asymptomatic and symptomatic hypocalcemia in the two groups was 19.8% and 15.8%, respectively.
Preoperative 25-OHD level was significantly different between Group 1 and Group 2 (31.5 ± 15.0 ng/mL vs 18.7 ± 9.8 ng/mL,p=0.017).
Logistic regression analysis revealed that preoperative vitamin D deficiency was a significant predictive factor of postoperative hypocalcemia (p=0.012), and, specifically, the risk of hypocalcemia increased 15-fold in patients with a preoperative vitamin D level <25 ng/mL (odds ratio [OR], 14.8).
Conclusions.
Postoperative hypocalcemia is significantly associated with low preoperative levels of serum 25-OHD.
Our studies demonstrate that vitamin D deficiency (<25 ng/mL) is an independent predictive factor of postoperative hypocalcemia.
American Psychological Association (APA)
Bove, A.& Dei Rocini, C.& Di Renzo, R. M.& Farrukh, M.& Palone, G.& Chiarini, S.…[et al.]. 2020. Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170558
Modern Language Association (MLA)
Bove, A.…[et al.]. Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy. International Journal of Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1170558
American Medical Association (AMA)
Bove, A.& Dei Rocini, C.& Di Renzo, R. M.& Farrukh, M.& Palone, G.& Chiarini, S.…[et al.]. Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1170558
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170558