Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways
Joint Authors
Nigro, Ersilia
Perrotta, Fabio
Polito, Rita
D’Agnano, Vito
Scialò, Filippo
Bianco, Andrea
Daniele, Aurora
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Coronavirus disease (COVID-19) is caused by SARS-CoV-2 virus, which can result in serious respiratory illnesses such as pneumonia leading to respiratory failure.
It was first reported in Wuhan, Hubei, China, in December 2019 and rapidly spread globally, becoming a pandemic in March 2020.
Among comorbidities observed in SARS-CoV-2 positive patients, hypertension (68.3%) and type 2-diabetes (30.1%) are the most frequent conditions.
Although symptoms are highly heterogeneous (ranging from absence of symptoms to severe acute respiratory failure), patients with metabolic-associated diseases often experience worse COVID-19 outcomes.
This review investigates the association between metabolic disorders and COVID-19 severity, exploring the molecular mechanisms potentially underlying this relationship and those that are responsible for more severe COVID-19 outcomes.
In addition, the role of the main biological processes that may connect metabolic alterations to SARS-CoV-2 infection such as hyperglycemia, immune system deregulation, ACE-2 receptor modulation, and inflammatory response is described.
The impact of metabolic disorders on the prognosis of COVID-19 has major implications in public health especially for countries affected by a high incidence of metabolic diseases.
American Psychological Association (APA)
Nigro, Ersilia& Perrotta, Fabio& Polito, Rita& D’Agnano, Vito& Scialò, Filippo& Bianco, Andrea…[et al.]. 2020. Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1170577
Modern Language Association (MLA)
Nigro, Ersilia…[et al.]. Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways. International Journal of Endocrinology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1170577
American Medical Association (AMA)
Nigro, Ersilia& Perrotta, Fabio& Polito, Rita& D’Agnano, Vito& Scialò, Filippo& Bianco, Andrea…[et al.]. Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1170577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170577