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Design, Synthesis, Antihyperglycemic Studies, and Docking Simulations of Benzimidazole-Thiazolidinedione Hybrids
Joint Authors
Almanza-Pérez, Julio César
Gutierréz-Hernández, Abraham
Galván-Ciprés, Yelzyn
Domínguez-Mendoza, Elix Alberto
Aguirre-Vidal, Yoshajandith
Estrada-Soto, Samuel
Navarrete-Vázquez, Gabriel
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A simple and cheap three-step procedure for the synthesis of three (5Z)-5-[3(4)-(1H-benzimidazol-2-ylmethoxy)benzylidene]-1,3-thiazolidine-2,4-diones has been described via a SN2 reaction of generally recognized as safe hydroxybenzaldehydes and 2-(chloromethyl)-1H-benzimidazole, followed by a Knoevenagel condensation with thiazolidine-2,4-dione in moderated yields.
All the newly synthesized compounds were characterized using analytical and spectral studies.
In vitro treatment on adipocytes with compounds increased the mRNA expression of two proteins recognized as strategic targets in diabetes: PPARγ and GLUT-4.
In silico studies were conducted in order to explain the interaction binding mode of the synthesized compounds on PPARγ.
In vivo studies confirmed that compounds 1–3 have robust antihyperglycemic action linked to insulin sensitization mechanisms.
The present study provides three compounds with a promising antidiabetic action.
American Psychological Association (APA)
Gutierréz-Hernández, Abraham& Galván-Ciprés, Yelzyn& Domínguez-Mendoza, Elix Alberto& Aguirre-Vidal, Yoshajandith& Estrada-Soto, Samuel& Almanza-Pérez, Julio César…[et al.]. 2019. Design, Synthesis, Antihyperglycemic Studies, and Docking Simulations of Benzimidazole-Thiazolidinedione Hybrids. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1170628
Modern Language Association (MLA)
Gutierréz-Hernández, Abraham…[et al.]. Design, Synthesis, Antihyperglycemic Studies, and Docking Simulations of Benzimidazole-Thiazolidinedione Hybrids. Journal of Chemistry No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1170628
American Medical Association (AMA)
Gutierréz-Hernández, Abraham& Galván-Ciprés, Yelzyn& Domínguez-Mendoza, Elix Alberto& Aguirre-Vidal, Yoshajandith& Estrada-Soto, Samuel& Almanza-Pérez, Julio César…[et al.]. Design, Synthesis, Antihyperglycemic Studies, and Docking Simulations of Benzimidazole-Thiazolidinedione Hybrids. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1170628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170628