Comparison of Erythrocyte Membrane Lipid Profiles between NAFLD Patients with or without Hyperlipidemia
Joint Authors
Bo, Tao
Yao, Zhenyu
Han, Jie
Zhao, Jiajun
Zhang, Qunye
Guo, Tian
Shao, Shanshan
Yu, Chunxiao
Chen, Wenbin
Zhao, Meng
Cai, Hu
Fu, Yilin
Xu, Guowang
Hu, Chunxiu
Gao, Ling
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objectives.
Nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia (HL) are common metabolic disorders due to overnutrition and obesity.
NAFLD is often associated with hyperlipidemia.
The aim of this study was to identify and compare the erythrocyte membrane lipids profile in NAFLD patients with or without HL.
Methods.
A total of 112 subjects (with similar age and body mass index) were divided into four groups: (1) normal controls, (2) NAFLD alone, (3) HL alone, and (4) NAFLD combined with HL (NAFLD + HL).
Lipid was extracted from the erythrocyte membrane, and lipid profiles of subjects were analyzed by liquid chromatography mass spectrometry (LC-MS).
Results.
Data sets from 103 subjects were adopted for lipidomic analysis.
Significant changes of lipid species were observed in patient groups, especially in the HL group and NAFLD + HL group.
The HL group showed increased level of most lipid species, and decreased level of most lipid species was observed in the NAFLD + HL group.
The weight percent of myristic acid, stearic acid, erucic acid, and docosahexaenoic acid also showed distinct variation between different groups.
Conclusions.
NAFLD, HL, and NAFLD + HL all had an impact on lipid profiling of the erythrocyte membrane.
The influence of NAFLD alone is less important compared with HL.
Some lipids should be highlighted because of their specific role in cell function and systemic metabolism.
American Psychological Association (APA)
Chen, Wenbin& Shao, Shanshan& Cai, Hu& Han, Jie& Guo, Tian& Fu, Yilin…[et al.]. 2020. Comparison of Erythrocyte Membrane Lipid Profiles between NAFLD Patients with or without Hyperlipidemia. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1170638
Modern Language Association (MLA)
Chen, Wenbin…[et al.]. Comparison of Erythrocyte Membrane Lipid Profiles between NAFLD Patients with or without Hyperlipidemia. International Journal of Endocrinology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1170638
American Medical Association (AMA)
Chen, Wenbin& Shao, Shanshan& Cai, Hu& Han, Jie& Guo, Tian& Fu, Yilin…[et al.]. Comparison of Erythrocyte Membrane Lipid Profiles between NAFLD Patients with or without Hyperlipidemia. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1170638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170638