Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?

Joint Authors

Giagulli, Vito Angelo
Bruno, Carmine
Mordente, Alvaro
Vincenzo, Triggiani
Silvestrini, Andrea
Mancini, Antonio

Source

International Journal of Endocrinology

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-01-21

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

Hypogonadotropic hypogonadism (HH) can be sustained by organic or functional alterations of the hypothalamic-pituitary-testicular axis.

Functional HH is related to systemic alterations, such as obesity or chronic inflammatory diseases, but could contribute to a negative course of the illness.

For such situation, according to results obtained in infertile women, the administration of selective estrogen receptor modulators (SERMs) has been proposed in males too, with positive results on both metabolic and sexual function.

This class of medications increases gonadotropin levels via antagonism to the estrogenic receptor; similar biological effects are also exerted by aromatase inhibitors (AIs), despite different mechanism of action.

After a brief review of trials regarding SERMs and AIs use in male HH, we describe the structure and function of the androgen receptor (AR) as a basis for clinical research about compounds able to bind to AR, in order to obtain specific effects (SARMs).

The tissue selectivity and different metabolic fate in comparison to testosterone can potentiate anabolic versus androgenic effects; therefore, they might be a valid alternative to testosterone replacement therapy avoiding the negative effects of testosterone (i.e., on prostate, liver, and hematopoiesis).

Trials are still at an early phase of investigation and, at the moment, the application seems to be more useful for chronic disease with catabolic status while the validation as replacement for hypogonadism requires further studies.

American Psychological Association (APA)

Giagulli, Vito Angelo& Silvestrini, Andrea& Bruno, Carmine& Vincenzo, Triggiani& Mordente, Alvaro& Mancini, Antonio. 2020. Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170668

Modern Language Association (MLA)

Giagulli, Vito Angelo…[et al.]. Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?. International Journal of Endocrinology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1170668

American Medical Association (AMA)

Giagulli, Vito Angelo& Silvestrini, Andrea& Bruno, Carmine& Vincenzo, Triggiani& Mordente, Alvaro& Mancini, Antonio. Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1170668

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1170668