Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8
Joint Authors
Wen, Fengyun
Xia, Qiao
Zhang, Hui
Shia, Haipeng
Rajesh, Amin
Wu, Yanling
Yang, Yi
Yang, Zaiqing
Source
International Journal of Endocrinology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Resistin is associated with metabolic syndrome and inflammatory conditions.
Many studies have suggested that resistin inhibits the accumulation of glycogen; however, the exact mechanisms of resistin-induced decrease in glycogen content remain unclear.
Keratin 8 is a typical epithelial intermediate filament protein, but numerous studies suggest a vital role of K8 in glucose metabolism.
However, it is still not known whether K8 participates in the mediation of resistin-induced reduction of cellular glycogen accumulation.
In this study, we found that resistin upregulated expression of the p65 subunit of NF-κB, which led to the promotion of K8 transcriptional expression; in turn, the expression of K8 inhibited glycogen accumulation in HepG2 cells.
American Psychological Association (APA)
Wen, Fengyun& Xia, Qiao& Zhang, Hui& Shia, Haipeng& Rajesh, Amin& Wu, Yanling…[et al.]. 2020. Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170681
Modern Language Association (MLA)
Wen, Fengyun…[et al.]. Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8. International Journal of Endocrinology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1170681
American Medical Association (AMA)
Wen, Fengyun& Xia, Qiao& Zhang, Hui& Shia, Haipeng& Rajesh, Amin& Wu, Yanling…[et al.]. Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170681