Resistin Activates p65 Pathway and Reduces Glycogen Content through Keratin 8

Abstract EN

Resistin is associated with metabolic syndrome and inflammatory conditions.

Many studies have suggested that resistin inhibits the accumulation of glycogen; however, the exact mechanisms of resistin-induced decrease in glycogen content remain unclear.

Keratin 8 is a typical epithelial intermediate filament protein, but numerous studies suggest a vital role of K8 in glucose metabolism.

However, it is still not known whether K8 participates in the mediation of resistin-induced reduction of cellular glycogen accumulation.

In this study, we found that resistin upregulated expression of the p65 subunit of NF-κB, which led to the promotion of K8 transcriptional expression; in turn, the expression of K8 inhibited glycogen accumulation in HepG2 cells.