Enaminone-Derived Pyrazoles with Antimicrobial Activity
Joint Authors
Bhat, Mashooq A.
Khan, Abdul Arif
Naglah, Ahmed M.
al-Omar, Mohamed A.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A series of pyrazoles derived from the substituted enaminones were synthesized and were evaluated for antimicrobial activity.
All the compounds were characterized by the spectral data and elemental analysis.
The synthesized compounds were initially screened for their antimicrobial activity against ATCC 6538, NCTC 10400, NCTC 10418, and ATCC 27853.
During initial screening, compounds (P1, P6, and P11) presented significant antimicrobial activity through disc diffusion assay.
These compounds were further evaluated for antimicrobial activity at different time points against Gram-positive and Gram-negative bacteria and presented significant activity for 6 hours.
The activity was found to be greater against Gram-positive bacteria.
In contrast at 24 hours, the activity was found only against Gram-positive bacteria except compound (P11), showing activity against both types of bacteria.
Compound (P11) was found to have highest activity against both Gram-positive and Gram-negative bacteria.
American Psychological Association (APA)
Bhat, Mashooq A.& al-Omar, Mohamed A.& Naglah, Ahmed M.& Khan, Abdul Arif. 2019. Enaminone-Derived Pyrazoles with Antimicrobial Activity. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1170718
Modern Language Association (MLA)
Bhat, Mashooq A.…[et al.]. Enaminone-Derived Pyrazoles with Antimicrobial Activity. Journal of Chemistry No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1170718
American Medical Association (AMA)
Bhat, Mashooq A.& al-Omar, Mohamed A.& Naglah, Ahmed M.& Khan, Abdul Arif. Enaminone-Derived Pyrazoles with Antimicrobial Activity. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1170718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170718