Synthesis and Characterization of Novel Biginelli Dihydropyrimidinone Derivatives Containing Imidazole Moiety
Joint Authors
Al-Dhfyan, Abdullah
Bhat, Mashooq A.
Naglah, Ahmed M.
Kalmouch, Atef
al-Omar, Mohamed A.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Enaminone, (2E)-1-[4-(1H-imidazol-1-yl) phenyl]-4-methylpent-2-en-1-one (II) was synthesized by refluxing 1-[4-(1H-imidazol-1-yl) phenyl] ethan-1-one (I) with dimethylforamide dimethylacetal (DMF–DMA) under solvent-free condition for 12 hours.
Finally, the dihydropyrimidinone derivatives containing imidazole moiety (1–15) were obtained by reacting enaminone, (2E)-1-[4-(1H-imidazol-1-yl) phenyl]-4-methylpent-2-en-1-one (II) with urea and different substituted benzaldehydes in the presence of glacial acetic acid.
Dihydropyrimidinone derivatives containing imidazole moiety were synthesized in excellent yield by means of a simple and efficient method.
All the compounds were confirmed by elemental analysis.
The structures of all the compounds were confirmed by modern spectroscopic methods.
American Psychological Association (APA)
Bhat, Mashooq A.& al-Omar, Mohamed A.& Naglah, Ahmed M.& Kalmouch, Atef& Al-Dhfyan, Abdullah. 2019. Synthesis and Characterization of Novel Biginelli Dihydropyrimidinone Derivatives Containing Imidazole Moiety. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1170854
Modern Language Association (MLA)
Bhat, Mashooq A.…[et al.]. Synthesis and Characterization of Novel Biginelli Dihydropyrimidinone Derivatives Containing Imidazole Moiety. Journal of Chemistry No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1170854
American Medical Association (AMA)
Bhat, Mashooq A.& al-Omar, Mohamed A.& Naglah, Ahmed M.& Kalmouch, Atef& Al-Dhfyan, Abdullah. Synthesis and Characterization of Novel Biginelli Dihydropyrimidinone Derivatives Containing Imidazole Moiety. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1170854
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170854