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Determination of the Lipophilicity of Ibuprofen, Naproxen, Ketoprofen, and Flurbiprofen with Thin-Layer Chromatography
Author
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The lipophilicity is an important parameter that influences the activity of the drugs in the human body.
The reversed phase high performance thin layer chromatography was applied to determine the Log P values of ibuprofen, ketoprofen, naproxen, and flurbiprofen.
The stationary phase used in the study was silica-gel coated plates.
The mobile phase was the mixture of acetonitrile and water in different proportions.
The content of acetonitrile varied in 5% increments from 50% to 80%.
The Rm0 values were determined for the compounds with a known Log P and for the analyzed substances (ibuprofen, naproxen, ketoprofen, and flurbiprofen).
The Log P values were calculated for the analyzed compounds using the regression curve Rm0 = f(Log P) parameters for the compounds with the known lipophilicity.
Flurbiprofen is characterized by the highest Log P value: 3.82.
The lowest one is noted for ketoprofen: 2.66.
The determined Log P values of tested compounds were similar to the values calculated by the software.
American Psychological Association (APA)
Czyrski, Andrzej. 2019. Determination of the Lipophilicity of Ibuprofen, Naproxen, Ketoprofen, and Flurbiprofen with Thin-Layer Chromatography. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1170901
Modern Language Association (MLA)
Czyrski, Andrzej. Determination of the Lipophilicity of Ibuprofen, Naproxen, Ketoprofen, and Flurbiprofen with Thin-Layer Chromatography. Journal of Chemistry No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1170901
American Medical Association (AMA)
Czyrski, Andrzej. Determination of the Lipophilicity of Ibuprofen, Naproxen, Ketoprofen, and Flurbiprofen with Thin-Layer Chromatography. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1170901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170901