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Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries
Joint Authors
Tamagno, Gianluca
Agasarova, Asta
Harnett, Clare
Mulligan, Niall
Majeed, Muhammad Shakeel
Caimo, Alberto
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bronchial neuroendocrine tumors (NET) are classified into well-differentiated typical carcinoids (TC), atypical carcinoids (AC), large cell neuroendocrine carcinomas (LCNEC), and small cell lung carcinomas (SCLC).
We retrospectively reviewed and analyzed the diagnostic and therapeutic aspects, follow-up data, and outcomes of all patients diagnosed with a bronchial NET from 1995 to 2015 at our institution.
Patients with LCNEC or SCLC were excluded due to the biological and clinical differences from the other bronchial NET.
The clinical, laboratory, imaging, treatment, and follow-up data were collected and analyzed keeping in mind the recently published international recommendations.
Forty-six patients were included in the study.
Of these, 37 had a TC and 5 an AC.
In 4 patients, the histological characterization was inadequate.
Forty-four patients underwent surgery.
Four patients developed metastatic disease.
Interestingly, 14 patients had one or more other tumors diagnosed at some stage and 3 of them had three different tumors.
A total of 7 patients died.
The analysis of the laboratory and pathology assessment identified some inconsistencies when compared to the international recommendations.
Although the treatment of bronchial NET at our institution was consistent with the successively published recommendations, it appears that the diagnostic process and the follow-up surveillance were not.
We think that a systematic multidisciplinary approach might improve bronchial NET patient care.
A relatively high rate of occurrence of a second, or also a third, non-NET tumor was observed, though the statistical value of such observation could not be exhaustively elucidated in this numerically limited patient population.
In our opinion, the observed high rate of second malignancies in this patient cohort highlights the necessity of optimizing the follow-up of the bronchial NET patients, also considering the very good survival rate achieved with regard to the bronchial NET.
American Psychological Association (APA)
Agasarova, Asta& Harnett, Clare& Mulligan, Niall& Majeed, Muhammad Shakeel& Caimo, Alberto& Tamagno, Gianluca. 2018. Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1170977
Modern Language Association (MLA)
Agasarova, Asta…[et al.]. Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1170977
American Medical Association (AMA)
Agasarova, Asta& Harnett, Clare& Mulligan, Niall& Majeed, Muhammad Shakeel& Caimo, Alberto& Tamagno, Gianluca. Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1170977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1170977