Autoimmune Diseases in Patients with Cushing’s Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review
Joint Authors
Giorgio, De Toma
Concistrè, Antonio
Olmati, Federica
Conforti, Maria Gabriella
Alfieri, Nikita
Iannucci, Gino
Claudio, Letizia
Bisogni, Valeria
Petramala, Luigi
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Cushing’s syndrome (CS) is a clinical condition characterized by excessive cortisol production, associated with metabolic complications, such as diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, and cardiovascular diseases.
Nowadays, the occurrence of autoimmune diseases in CS have not been completely evaluated in the previous studies.
Objective.
The aim of this study was to evaluate the occurrence of autoimmune diseases in CS patients after successfully treated.
Materials and Methods.
From January 2001 to December 2017, in our Secondary Hypertension Unit, we evaluated 147 CS patients (91 with ACTH-independent disease, 54 with ACTH-dependent disease, and 2 patients with ectopic ACTH production.
Results.
109 CS patients (74.1%) were surgically treated (67 ACTH-independent CS patients (61.5%) undergone adrenalectomy and 42 ACTH-dependent CS (38.5%) undergone transsphenoidal surgery) and evaluated after 6, 12, and 24 months after clinical and biochemical remission of disease.
In 9 (8.3%) of overall treated CS patients (8.3%), during follow-up, we observed the onset of some manifestations of autoimmune diseases.
In particular, one patient had a systemic lupus erythematosus, one patient had rheumatoid arthritis, 4 patients reported autoimmune thyroiditis (Basedow-Graves’ disease and Hashimoto’s thyroiditis), one patient had clinical features of psoriasis, one patient showed myasthenia gravis, and one patient had giant cell arteritis.
Conclusions.
Our results demonstrate that patients successfully treated for CS could develop autoimmune diseases.
Therefore, after treatment, CS patients need to be strictly monitored in order to evaluate the possible onset of autoimmune diseases.
American Psychological Association (APA)
Petramala, Luigi& Olmati, Federica& Conforti, Maria Gabriella& Concistrè, Antonio& Bisogni, Valeria& Alfieri, Nikita…[et al.]. 2018. Autoimmune Diseases in Patients with Cushing’s Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171016
Modern Language Association (MLA)
Petramala, Luigi…[et al.]. Autoimmune Diseases in Patients with Cushing’s Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171016
American Medical Association (AMA)
Petramala, Luigi& Olmati, Federica& Conforti, Maria Gabriella& Concistrè, Antonio& Bisogni, Valeria& Alfieri, Nikita…[et al.]. Autoimmune Diseases in Patients with Cushing’s Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171016