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CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers
Joint Authors
Antonelli, Alessandro
Ulisse, S.
Baldini, Enke
Monti, Massimo
Mian, Caterina
Barollo, Susi
Sorrenti, Salvatore
Tartaglia, Francesco
Arcieri, Stefano
Catania, Antonio
Tuccilli, Chiara
Fallahi, Poupak
Palmieri, Andrea
Carbotta, Giovanni
Pironi, Daniele
Vergine, Massimo
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance.
Here, the expression of PD-L1, PD-L2, CD80, and CD86 was evaluated at the mRNA level in 94 patients affected by papillary thyroid carcinoma (PTC) and 11 patients affected by anaplastic thyroid carcinoma (ATC).
Variations in the mRNAs in PTC patients were then correlated with clinicopathological features.
The expression of all genes was deregulated in PTC and ATC tissues compared to normal tissues.
In particular, the downregulation of CD80 was observed above all in ATC.
In addition, the increased expression of CD80 associated with longer disease-free survival in PTC.
Higher expression of PD-L1 associated with the classical histological variant and with the presence of BRAFV600E mutation in PTC.
The increased PD-L2 expression correlated with BRAFV600E mutation and lymph node metastasis, while its lower expression correlated with the follicular PTC variant.
The latter was also associated with the CD80 downregulation, which was also related to the absence of lymph node metastasis.
In conclusion, we documented the overall dysregulation of PD-1 and CTLA-4 ligands in PTC and ATC tissues and a possible prognostic value for CD80 gene expression in PTC.
American Psychological Association (APA)
Tuccilli, Chiara& Baldini, Enke& Sorrenti, Salvatore& Catania, Antonio& Antonelli, Alessandro& Fallahi, Poupak…[et al.]. 2018. CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1171049
Modern Language Association (MLA)
Tuccilli, Chiara…[et al.]. CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers. International Journal of Endocrinology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1171049
American Medical Association (AMA)
Tuccilli, Chiara& Baldini, Enke& Sorrenti, Salvatore& Catania, Antonio& Antonelli, Alessandro& Fallahi, Poupak…[et al.]. CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1171049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171049