Implication of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, and Subclinical Inflammation on Mild Renal Insufficiency
Joint Authors
Baik, Sei Hyun
Nam, Ga Eun
Hwang, Soon Young
Chung, Hye Soo
Choi, Ju Hee
Lee, Hyun Jung
Kim, Nam Hoon
Yoo, Hye Jin
Seo, Ji-A
Kim, Sin Gon
Kim, Nan Hee
Choi, Kyung Mook
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Limited information exists about the impact of nonalcoholic fatty liver disease (NAFLD) on mild renal insufficiency.
We compared the relative influence of NAFLD, metabolic syndrome (MetS), and subclinical inflammation, alone or in combination, on mild renal insufficiency.
Methods.
This study included 1174 Korean adults.
NAFLD was diagnosed using ultrasonography.
Mild renal insufficiency was defined as an estimated glomerular filtration rate (eGFR) ≥ 60 and <90 mL/min/1.73 m2.
Results.
In partial correlation analysis, several components of MetS and liver aminotransferase levels, but not high-sensitivity C-reactive protein (hsCRP), were associated with eGFR.
Multivariate logistic regression analysis demonstrated the independent association of NAFLD (P=0.034) and MetS (P=0.018) with mild renal insufficiency, but not elevated hsCRP (P=0.885).
Furthermore, NAFLD without the MetS group (odds ratio (95% confidence interval) = 1.56 (1.05–2.34)) or MetS without the NAFLD group (1.82 (1.11–3.00)) was associated with mild renal insufficiency after adjusting for confounding variables.
However, individuals with high hsCRP showed no relationship with mild renal insufficiency, irrespective of the existence of NAFLD.
Conclusions.
This study demonstrated that NAFLD and MetS are independently associated with mild renal insufficiency, whereas subclinical inflammation did not affect the risk for mild renal insufficiency in Korean adults.
American Psychological Association (APA)
Nam, Ga Eun& Hwang, Soon Young& Chung, Hye Soo& Choi, Ju Hee& Lee, Hyun Jung& Kim, Nam Hoon…[et al.]. 2018. Implication of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, and Subclinical Inflammation on Mild Renal Insufficiency. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171074
Modern Language Association (MLA)
Nam, Ga Eun…[et al.]. Implication of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, and Subclinical Inflammation on Mild Renal Insufficiency. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171074
American Medical Association (AMA)
Nam, Ga Eun& Hwang, Soon Young& Chung, Hye Soo& Choi, Ju Hee& Lee, Hyun Jung& Kim, Nam Hoon…[et al.]. Implication of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, and Subclinical Inflammation on Mild Renal Insufficiency. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171074