Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans
Joint Authors
Song, Kexiu
Qu, Shen
Gusdon, Aaron M.
Wang, XingChun
Chen, Jiaqi
Sun, Hang
Li, Liang
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
This study aimed to determine the effects of melatonin on insulin resistance in obese patients with acanthosis nigricans (AN).
Methods.
A total of 17 obese patients with acanthosis nigricans were recruited in a 12-week pilot open trial.
Insulin sensitivity, glucose metabolism, inflammatory factors, and other biochemical parameters before and after the administration of melatonin were measured.
Results.
After 12 weeks of treatment with melatonin (3 mg/day), homeostasis model assessment insulin resistance index (HOMA-IR) (8.99 ± 5.10 versus 7.77 ± 5.21, p<0.05) and fasting insulin (37.09 5 ± 20.26 μU/ml versus 32.10 ± 20.29 μU/ml, p<0.05) were significantly decreased.
Matsuda index (2.82 ± 1.54 versus 3.74 ± 2.02, p<0.05) was significantly increased.
There were also statistically significant declines in the AN scores of the neck and axilla, body weight, body mass index, body fat, visceral index, neck circumference, waist circumference, and inflammatory markers.
Conclusions.
It was concluded that melatonin could improve cutaneous symptoms in obese patients with acanthosis nigricans by improving insulin sensitivity and inflammatory status.
This trial is registered with ClinicalTrials.gov NCT02604095.
American Psychological Association (APA)
Sun, Hang& Wang, XingChun& Chen, Jiaqi& Gusdon, Aaron M.& Song, Kexiu& Li, Liang…[et al.]. 2018. Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171152
Modern Language Association (MLA)
Sun, Hang…[et al.]. Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171152
American Medical Association (AMA)
Sun, Hang& Wang, XingChun& Chen, Jiaqi& Gusdon, Aaron M.& Song, Kexiu& Li, Liang…[et al.]. Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171152