The Combined Effect of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome on Osteoporosis in Postmenopausal Females in Eastern China
Joint Authors
Zhang, Ling-Jian
Shi, Hongying
Chen, Da-Zhi
Xu, Qiao-Mai
Wu, Xiao-Xin
Cai, Chao
Shi, Ke-Qing
Li, Lanjuan
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study evaluated the potential combined effects of NAFLD and MetS on the development of osteoporosis.
The relationship between NAFLD and MetS and osteoporosis was assessed in 938 postmenopausal female participants.
Moderate and severe NAFLDs were combined as significant NAFLD (SNAFLD).
All the subjects were divided into 4 subgroups based on the status of SNAFLD and MetS.
Relative excess risk of interaction (RERI), attributable proportion (AP) of interaction, and synergy index (SI) were used to investigate the additive interaction of those two factors.
NAFLD, SNAFLD, and MetS were independent factors for osteoporosis with the adjustment of age and other confounders.
The incidence of osteoporosis in MetS (+) SNAFLD (+) group was significantly higher than that in other three groups.
RERI was 2.556 (95% CI = 0.475–4.636), AP was 0.454 (95% CI = 0.201–0.706), and SI was 2.231 (95% CI = 1.124 to 4.428), indicating the significant combined interaction of SNAFLD and MetS on the development of osteoporosis.
SNAFLD and MetS are independent risk factors for osteoporosis in postmenopausal females, respectively.
Moreover, SNAFLD and MetS have an additive effect on the development of osteoporosis.
American Psychological Association (APA)
Chen, Da-Zhi& Xu, Qiao-Mai& Wu, Xiao-Xin& Cai, Chao& Zhang, Ling-Jian& Shi, Ke-Qing…[et al.]. 2018. The Combined Effect of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome on Osteoporosis in Postmenopausal Females in Eastern China. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171156
Modern Language Association (MLA)
Chen, Da-Zhi…[et al.]. The Combined Effect of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome on Osteoporosis in Postmenopausal Females in Eastern China. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1171156
American Medical Association (AMA)
Chen, Da-Zhi& Xu, Qiao-Mai& Wu, Xiao-Xin& Cai, Chao& Zhang, Ling-Jian& Shi, Ke-Qing…[et al.]. The Combined Effect of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome on Osteoporosis in Postmenopausal Females in Eastern China. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171156