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Association Study of Puberty-Related Candidate Genes in Chinese Female Population
Joint Authors
Source
International Journal of Genomics
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Puberty is a transition period where a child transforms to an adult.
Puberty can be affected by various genetic factors and environmental influences.
In mammals, the regulation of puberty is enhanced by the hypothalamic-pituitary-gonadal axis (HPG axis).
A number of genes such as GnRH, Kiss1, and GPR54 have been reported as key regulators of puberty onset.
In this study, we have conducted an association study of puberty-related candidate genes in Chinese female population.
Gene variations reported to be related with some traits in a population may not exist in others due to different genetic and ethnic backgrounds, hence the need for this kind of study.
The genotyping of SNPs was based on multiplex PCR and the next-generation sequencing (NGS) platform of Illumina.
We finally performed association study using PLINK software.
Our results confirmed that SNPs rs34787247 in LIN28, rs74795793 and rs9347389 in OCT-1, and rs379202 and rs10491080 in ZEB1 genes showed a significant association with puberty.
With the result, it is reasonable to conclude that these genes affect the process of puberty in Shanghai Chinese female population, yet the mechanism remains to be investigated by further study.
American Psychological Association (APA)
Omariba, Gideon& Xiao, Junhua. 2020. Association Study of Puberty-Related Candidate Genes in Chinese Female Population. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171175
Modern Language Association (MLA)
Omariba, Gideon& Xiao, Junhua. Association Study of Puberty-Related Candidate Genes in Chinese Female Population. International Journal of Genomics No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1171175
American Medical Association (AMA)
Omariba, Gideon& Xiao, Junhua. Association Study of Puberty-Related Candidate Genes in Chinese Female Population. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171175