Uterine Artery Doppler in Pregnancy: Women with PCOS Compared to Healthy Controls
Joint Authors
Salvesen, Øyvind
Stridsklev, Solhild
Salvesen, Kjell Åsmund
Carlsen, Sven M.
Vanky, Eszter
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The objective of this study was to investigate possible differences in uterine artery pulsatility index (UtAPI) between pregnant women with PCOS and healthy controls and to explore possible effects of metformin on UtAPI.
Material and Methods.
The study was conducted in a tertiary center.
Forty-eight pregnant women diagnosed with PCOS before pregnancy and 124 healthy pregnant women were included.
Women with PCOS were randomly assigned to metformin 2000 mg daily or a placebo.
UtAPI was measured five times during 1st and 2nd trimesters of pregnancy in women with PCOS and four times in healthy controls.
Results.
There was no difference in UtAPI between PCOS women and healthy controls at any point in time (p=0.34–0.77).
In women with PCOS, randomly assigned to metformin 2000 mg or placebo, UtAPI was unaffected by metformin two hours after intake of the first dose of study medication (p=0.34).
All PCOS women, regardless of randomization, had higher UtAPI two hours after intake of study medication and a meal compared to before a meal (p=0.02).
Conclusions.
In the first and second trimesters of pregnancy, there was no difference in UtAPI between women with PCOS and healthy controls.
Metformin had no immediate effect on the UtAPI.
Interestingly, blood flow decreased after a meal, suggesting that time since last meal should be taken into consideration when interpreting the results of UtAPI measurements in pregnancy.
This trial is registered with ClinicalTrials.gov (NCT00466622) Metformin in Pregnant PCOS women (PregMet) (NCT00159536).
American Psychological Association (APA)
Stridsklev, Solhild& Salvesen, Øyvind& Salvesen, Kjell Åsmund& Carlsen, Sven M.& Vanky, Eszter. 2018. Uterine Artery Doppler in Pregnancy: Women with PCOS Compared to Healthy Controls. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1171180
Modern Language Association (MLA)
Stridsklev, Solhild…[et al.]. Uterine Artery Doppler in Pregnancy: Women with PCOS Compared to Healthy Controls. International Journal of Endocrinology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1171180
American Medical Association (AMA)
Stridsklev, Solhild& Salvesen, Øyvind& Salvesen, Kjell Åsmund& Carlsen, Sven M.& Vanky, Eszter. Uterine Artery Doppler in Pregnancy: Women with PCOS Compared to Healthy Controls. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1171180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171180