Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue
Joint Authors
Dias, Sofia
Paredes, Sílvia
Ribeiro, Laura
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-17
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Metabolic syndrome can be defined as a state of disturbed metabolic homeostasis characterized by visceral obesity, atherogenic dyslipidemia, arterial hypertension, and insulin resistance.
The growing prevalence of metabolic syndrome will certainly contribute to the burden of cardiovascular disease.
Obesity and dyslipidemia are main features of metabolic syndrome, and both can present with adipose tissue dysfunction, involved in the pathogenic mechanisms underlying this syndrome.
We revised the effects, and underlying mechanisms, of the current approved drugs for dyslipidemia and obesity (fibrates, statins, niacin, resins, ezetimibe, and orlistat; sibutramine; and diethylpropion, phentermine/topiramate, bupropion and naltrexone, and liraglutide) on adipose tissue.
Specifically, we explored how these drugs can modulate the complex pathways involved in metabolism, inflammation, atherogenesis, insulin sensitivity, and adipogenesis.
The clinical outcomes of adipose tissue modulation by these drugs, as well as differences of major importance for clinical practice between drugs of the same class, were identified.
Whether solutions to these issues will be found in further adjustments and combinations between drugs already in use or necessarily in new advances in pharmacology is not known.
To better understand the effect of drugs used in dyslipidemia and obesity on adipose tissue not only is challenging for physicians but could also be the next step to tackle cardiovascular disease.
American Psychological Association (APA)
Dias, Sofia& Paredes, Sílvia& Ribeiro, Laura. 2018. Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1171183
Modern Language Association (MLA)
Dias, Sofia…[et al.]. Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue. International Journal of Endocrinology No. 2018 (2018), pp.1-21.
https://search.emarefa.net/detail/BIM-1171183
American Medical Association (AMA)
Dias, Sofia& Paredes, Sílvia& Ribeiro, Laura. Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1171183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171183