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Value of Apoptotic, Antiapoptotic, and Cell Proliferation Markers in the Treatment of Graves’ Disease
Joint Authors
Zantut-Wittmann, Denise E.
Siqueira Barreto, Icléia
Vasconcelos, Jessica Castro de
Matos, Patrícia Sabino
Maia, Frederico Fernandes Ribeiro
Parisi, Maria Cândida Ribeiro
Tambascia, M.
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To better understand the genesis of autoimmunity in Graves’ disease (GD), it is essential to study the mechanism of apoptosis and cell proliferation in thyroid cells and intrathyroidal lymphocytic infiltrate of GD patients.
Methods.
A cross sectional, observational study performed by evaluating histopathological samples of thyroidectomy products from GD patients using immunohistochemistry.
New histological sections were prepared for immunohistochemical analysis with markers of cell proliferation, antiproliferation, apoptosis, and antiapoptosis.
Results.
Patients with GD who underwent radioiodine therapy (RIT) had a lower lymphocytic expression level of p27Kip1, and those who took beta-blockers had higher expression levels of BID (BH3-interacting domain) and a lower Ki-67 expression level in thyrocytes than those who did not.
The association of a shorter diagnostic time with a lower expression level of MCL-1 in thyroid cells suggests that the hyperthyroid state was related to a lower antiapoptotic effect on thyrocytes.
In comparison to patients with GD not using antithyroid drugs (ATD), we found a lower expression level of BID in lymphocytes for those who used ATD.
Conclusion.
In GD, the hyperthyroid state was associated with a lower antiapoptotic effect on thyroid cells.
RIT, beta-blockers, and thionamide act by stimulating apoptosis of thyrocytes by intrathyroidal lymphocytes.
American Psychological Association (APA)
Vasconcelos, Jessica Castro de& Siqueira Barreto, Icléia& Matos, Patrícia Sabino& Maia, Frederico Fernandes Ribeiro& Tambascia, M.& Parisi, Maria Cândida Ribeiro…[et al.]. 2018. Value of Apoptotic, Antiapoptotic, and Cell Proliferation Markers in the Treatment of Graves’ Disease. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171224
Modern Language Association (MLA)
Vasconcelos, Jessica Castro de…[et al.]. Value of Apoptotic, Antiapoptotic, and Cell Proliferation Markers in the Treatment of Graves’ Disease. International Journal of Endocrinology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1171224
American Medical Association (AMA)
Vasconcelos, Jessica Castro de& Siqueira Barreto, Icléia& Matos, Patrícia Sabino& Maia, Frederico Fernandes Ribeiro& Tambascia, M.& Parisi, Maria Cândida Ribeiro…[et al.]. Value of Apoptotic, Antiapoptotic, and Cell Proliferation Markers in the Treatment of Graves’ Disease. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171224