Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma
Joint Authors
Jin, Yiting
Zou, Qiang
Cao, Yun
Zhang, Wei
Source
International Journal of Genomics
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-14
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Heterogeneous nuclear ribonucleoproteins (HNRNPs) are crucial members in the pathogenesis and progression of numerous cancers.
However, the expression pattern and clinical significance of HNRNPs in breast carcinoma (BC) remain to be investigated.
In the present study, bioinformatic analysis identified HNRNPAB as the only commonly upregulated HNRNP in BC.
Elevated expression of HNRNPAB was positively associated with more aggressive diseases and poorer survival rates in BC.
Pathway analysis revealed that HNRNPAB coexpressed genes were enriched in the pathway of G2/M phase transition, and the expression level of HNRNPAB was strongly correlated with those of CCNB1, CDK1, CDC25A, and CDC25C.
Experiments in vitro demonstrated that HNRNPAB knockdown suppressed cell proliferation and blocked the G2/M phase transition in BC.
Taken together, this study provides the initial evidence that HNRNPAB may be employed as an innovative therapeutic target as well as a prognostic biomarker in BC patients.
American Psychological Association (APA)
Cao, Yun& Zhang, Wei& Jin, Yiting& Zou, Qiang. 2020. Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1171227
Modern Language Association (MLA)
Cao, Yun…[et al.]. Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma. International Journal of Genomics No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1171227
American Medical Association (AMA)
Cao, Yun& Zhang, Wei& Jin, Yiting& Zou, Qiang. Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1171227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171227