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An Efficient and Practical Method for the Synthesis of Saxagliptin Intermediate 2-(3-Hydroxy-1-adamantane)-2-oxoacetic Acid and Its Optimization
Joint Authors
Liao, Qi
Jiang, Lan
Li, Cong
Shen, Yaling
Wang, Min
Cao, Chengkun
Hu, Xiangnan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A mild and relatively simple way for preparation of 2-(3-hydroxy-1-adamantane)-2-oxoacetic acid (I) was reported.
It was prepared from 1-adamantanecarboxylic acid (II) via sulfuric acid/nitric acid to get 3-hydroxy-1-adamantanecarboxylic acid (III); treated with the one-pot method through acylation, condensation, and decarboxylation to obtain 3-hydroxy-1-acetyladamantane (IV); and finally oxidized by potassium permanganate (KMnO4) to get the target compound (I).
The overall yield was about 60%, which provides a new idea for commercial production of saxagliptin intermediate.
American Psychological Association (APA)
Liao, Qi& Jiang, Lan& Li, Cong& Shen, Yaling& Wang, Min& Cao, Chengkun…[et al.]. 2019. An Efficient and Practical Method for the Synthesis of Saxagliptin Intermediate 2-(3-Hydroxy-1-adamantane)-2-oxoacetic Acid and Its Optimization. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1171236
Modern Language Association (MLA)
Liao, Qi…[et al.]. An Efficient and Practical Method for the Synthesis of Saxagliptin Intermediate 2-(3-Hydroxy-1-adamantane)-2-oxoacetic Acid and Its Optimization. Journal of Chemistry No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1171236
American Medical Association (AMA)
Liao, Qi& Jiang, Lan& Li, Cong& Shen, Yaling& Wang, Min& Cao, Chengkun…[et al.]. An Efficient and Practical Method for the Synthesis of Saxagliptin Intermediate 2-(3-Hydroxy-1-adamantane)-2-oxoacetic Acid and Its Optimization. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1171236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171236