Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets
Joint Authors
Costa, Silvio Claudio da
Palma-Rigo, Kesia
Pavanello, Audrei
Piovan, Silvano
Peixoto, Giuliana Maria Ledesma
Matiusso, Camila Cristina Ianoni
de Moraes, Ana Maria Praxedes
Martins, Isabela Peixoto
Malta, Ananda
da Silva Franco, Claudinéia Conationi
Milani, Paula Gimenez
Dacome, Antonio Sérgio
de Freitas Mathias, Paulo Cezar
Mareze-Costa, Cecília Edna
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Stevia rebaudiana (Bert.) Bertoni besides being a source of noncaloric sweeteners is also an important source of bioactive molecules.
Many plant extracts, mostly obtained with ethyl acetate solvent, are rich in polyphenol compounds that present insulinotropic effects.
To investigate whether the nonsweetener fraction, which is rich in phenolic compounds isolated from Stevia rebaudiana with the solvent ethyl acetate (EAF), has an insulinotropic effect, including interference at the terminals of the autonomic nervous system of the pancreatic islets of rats.
Pancreatic islets were isolated from Wistar rats and incubated with EAF and inhibitory or stimulatory substances of insulin secretion, including cholinergic and adrenergic agonists and antagonists.
EAF potentiates glucose-stimulated insulin secretion (GSIS) only in the presence of high glucose and calcium-dependent concentrations.
EAF increased muscarinic insulinotropic effects in pancreatic islets, interfering with the muscarinic receptor subfamily M3.
Adrenergic inhibitory effects on GSIS were attenuated in the presence of EAF, which interfered with the adrenergic α2 receptor.
Results suggest that EAF isolated from stevia leaves is a potential therapy for treating type 2 diabetes mellitus by stimulating insulin secretion only in high glucose concentrations, enhancing parasympathetic signal transduction and inhibiting sympathetic signal transduction in beta cells.
American Psychological Association (APA)
Piovan, Silvano& Pavanello, Audrei& Peixoto, Giuliana Maria Ledesma& Matiusso, Camila Cristina Ianoni& de Moraes, Ana Maria Praxedes& Martins, Isabela Peixoto…[et al.]. 2018. Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171237
Modern Language Association (MLA)
Piovan, Silvano…[et al.]. Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171237
American Medical Association (AMA)
Piovan, Silvano& Pavanello, Audrei& Peixoto, Giuliana Maria Ledesma& Matiusso, Camila Cristina Ianoni& de Moraes, Ana Maria Praxedes& Martins, Isabela Peixoto…[et al.]. Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171237