Effect of Huangqin Tang on Colonic Gene Expression in Rats with Ulcerative Colitis
Joint Authors
Li, Yu
Wang, Dunfang
Ma, Xuran
Guo, Shanshan
Wang, Yanli
Li, Tao
Zou, Dixin
Song, Hongxin
Yang, Weipeng
Shi, KaiFeng
Xu, Hangyu
Liu, JiaXing
Source
International Journal of Genomics
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In this study, we explored the pharmacological mechanisms of Huangqin Tang (HQT; a traditional Chinese medicine formula) in ulcerative colitis (UC) and provided evidence for potential roles HQT plays by gene expression profiling.
The UC rat model was made via a compound method (trinitrobenzene sulfonic acid plus ethanol).
After a ten-day treatment, microarray analysis was performed from the colon segment of the rats.
Biological functions and specific signaling pathways were enriched based on differentially expressed genes (DEG), and corresponding gene networks were constructed via Ingenuity Pathway Analysis (IPA).
Through the network, we screened the potential “candidate targets,” such as ITGB1, FN1, CASP3, and ITGA5 and FABP1, ABCB1, FABP2, and SLC51B.
These potential candidate targets were functionally related to immune responses, inflammation, and metabolism.
Moreover, HQT significantly decreased serum levels of proinflammatory factors nitrogen monoxide (NO), proinflammatory cytokines interleukin- (IL-) 17, and prostaglandin E2 (PGE2).
The degree of HE staining of colonic tissue was severe in the model group but reduced significantly in the HQT group.
HQT exhibited protective effects against colon damage by inhibiting the inflammatory response.
American Psychological Association (APA)
Wang, Dunfang& Shi, KaiFeng& Wang, Yanli& Zou, Dixin& Guo, Shanshan& Li, Tao…[et al.]. 2020. Effect of Huangqin Tang on Colonic Gene Expression in Rats with Ulcerative Colitis. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1171238
Modern Language Association (MLA)
Wang, Dunfang…[et al.]. Effect of Huangqin Tang on Colonic Gene Expression in Rats with Ulcerative Colitis. International Journal of Genomics No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1171238
American Medical Association (AMA)
Wang, Dunfang& Shi, KaiFeng& Wang, Yanli& Zou, Dixin& Guo, Shanshan& Li, Tao…[et al.]. Effect of Huangqin Tang on Colonic Gene Expression in Rats with Ulcerative Colitis. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1171238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171238