Dysregulated Expression and Methylation Analysis Identified TLX1NB as a Novel Recurrence Marker in Low-Grade Gliomas
Joint Authors
Yuan, Changwei
Zhang, Jiayong
Duan, Hongzhou
Yang, Zuozhen
Shen, Shengli
Wang, Yingjin
Li, Chen
Source
International Journal of Genomics
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Low-grade gliomas (LGGs) are the most common CNS tumors, and the main therapy for LGGs is complete surgical resection, due to its curative effect.
However, LGG recurrence occurs frequently.
Biomarkers play a crucial role in evaluating the recurrence and prognosis of LGGs.
Numerous studies have focused on LGG prognosis.
However, the multiomics research investigating the roles played by gene methylation and expression in LGG recurrence remains limited.
In this study, we integrated the TCGA and GEO datasets, analyzing RNA and methylation data for recurrence (R) and nonrecurrence (NR) groups.
We found a low expression of TLX1NB and high methylation in recurrence patients.
Low expression of TLX1NB is associated with poor survival (OS: p=0.04).
The expression of TLX1NB is likely to play a role in the prognosis of LGG.
Therefore, TLX1NB may represent an alternative early biomarker for the recurrence of low-grade gliomas.
American Psychological Association (APA)
Duan, Hongzhou& Yang, Zuozhen& Li, Chen& Zhang, Jiayong& Shen, Shengli& Yuan, Changwei…[et al.]. 2020. Dysregulated Expression and Methylation Analysis Identified TLX1NB as a Novel Recurrence Marker in Low-Grade Gliomas. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171261
Modern Language Association (MLA)
Duan, Hongzhou…[et al.]. Dysregulated Expression and Methylation Analysis Identified TLX1NB as a Novel Recurrence Marker in Low-Grade Gliomas. International Journal of Genomics No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1171261
American Medical Association (AMA)
Duan, Hongzhou& Yang, Zuozhen& Li, Chen& Zhang, Jiayong& Shen, Shengli& Yuan, Changwei…[et al.]. Dysregulated Expression and Methylation Analysis Identified TLX1NB as a Novel Recurrence Marker in Low-Grade Gliomas. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1171261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171261
