Prevalence, Predictive Factors, and Characteristics of Osteoporosis in Hyperthyroid Patients
Joint Authors
Ogbera, Anthonia
Ale, Ayotunde O.
Ebili, Henry O.
Adeyemo, Olusola L.
Afe, Taiwo O.
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The osteoporosis in thyroid disorder has the lowest report especially in sub-Saharan Africa.
This study aims to determine the prevalence, predictive factors, and characteristics of osteoporosis in hyperthyroid patients.
Method.
Forty (40) hyperthyroid patients and healthy controls ages 21–50 years were recruited in this study.
Questionnaires were administered to capture bio- and clinical data.
Biochemical tests included blood, thyroid functions, intact parathyroid hormone, corrected calcium, and 25-hydroxyvitamin D tests.
Bone mineral density (BMD) was also evaluated.
Data were analyzed using the SPSS 21.
A p value < 0.05 was regarded as significant.
Results.
Osteoporosis was observed in 18 (45%) of study subjects, 13 (72.2%) females and 5 (27.8%) males, respectively.
The BMD of the hyperthyroid patients had a negative correlation with free triiodothyronine, FT3 (r=−0.49, p=0.005), FT4 (r=−0.33, p=0.009), corrected calcium (r=−0.31, p=0.039), alkaline phosphatase (r=−0.53, p<0.001), and osteocalcin (r=−0.61, p<0.001).
Conversely, a positive association with thyroid-stimulating hormone (TSH) (r=0.54, p<0.001) was observed.
Multiple regression showed osteocalcin (p<0.001) and TSH (p=0.015) as independent predictors of osteoporosis.
Conclusion.
Thyrotoxicosis is a risk factor for osteoporosis occurrence, and we recommend routine screening for this bone disease in persons over 20 years old with this disorder.
American Psychological Association (APA)
Ale, Ayotunde O.& Ogbera, Anthonia& Ebili, Henry O.& Adeyemo, Olusola L.& Afe, Taiwo O.. 2018. Prevalence, Predictive Factors, and Characteristics of Osteoporosis in Hyperthyroid Patients. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171273
Modern Language Association (MLA)
Ale, Ayotunde O.…[et al.]. Prevalence, Predictive Factors, and Characteristics of Osteoporosis in Hyperthyroid Patients. International Journal of Endocrinology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1171273
American Medical Association (AMA)
Ale, Ayotunde O.& Ogbera, Anthonia& Ebili, Henry O.& Adeyemo, Olusola L.& Afe, Taiwo O.. Prevalence, Predictive Factors, and Characteristics of Osteoporosis in Hyperthyroid Patients. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1171273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171273