The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion
Joint Authors
Miranda-Díaz, Alejandra Guillermina
Rodríguez-Lara, Simón Quetzalcoatl
García-Benavides, Leonel
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-04
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Ischemia-reperfusion (I/R) injury is a well-known phenomenon that involves different pathophysiological processes.
Connection in diverse systems of survival brings about cellular dysfunction or even apoptosis.
One of the survival systems of the cells, to the assault caused by ischemia, is the activation of the renin-angiotensin-aldosterone system (also known as an axis), which is focused on activating diverse signaling pathways to favor adaptation to the decrease in metabolic supports caused by the hypoxia.
In trying to adapt to the I/R event, great changes occur that unchain cellular dysfunction with the capacity to lead to cell death, which translates into a poor prognosis due to the progression of dysfunction of the cellular activity.
The search for the understanding of the diverse therapeutic alternatives in molecular coupling could favor the prognosis and evolution of patients who are subject to the I/R process.
American Psychological Association (APA)
Rodríguez-Lara, Simón Quetzalcoatl& García-Benavides, Leonel& Miranda-Díaz, Alejandra Guillermina. 2018. The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1171276
Modern Language Association (MLA)
Rodríguez-Lara, Simón Quetzalcoatl…[et al.]. The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion. International Journal of Endocrinology No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1171276
American Medical Association (AMA)
Rodríguez-Lara, Simón Quetzalcoatl& García-Benavides, Leonel& Miranda-Díaz, Alejandra Guillermina. The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1171276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171276