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Synthesis of Hybrid Fluoroquinolone-Boron Complexes and Their Evaluation in Cervical Cancer Cell Lines
Joint Authors
Chacón-García, Luis
Lopez, Jesús Adrián
Hernández-López, Hiram
Sánchez-Miranda, Griselda
Araujo-Huitrado, Jorge Gustavo
Granados-López, Angelica Judith
Leyva-Ramos, Socorro
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Quinolones are a family of antimicrobial agents that have been used in antibacterial and anticancer chemotherapy.
Fluoroquinolone targets DNA gyrase and topoisomerase IV enzymes affecting several cellular processes, like cell death and proliferation; the best way to act is in the form of carboxylic acid or, recently, as quinolone-metal complex.
In this work, the use of boron is shown as an alternative of metal to form a complex by incorporating to fluoroquinolone as an electron withdrawing substituent to activate the C-7 position chemoselectively for the production of new fluoroquinolone hybrids and test their effects on cell proliferation.
Fluoroquinolone-boron complexes were synthesized according to the Gould–Jacobs cyclization method, and five hybrid fluoroquinolone-boron compounds were obtained by SNAr reaction, yielding 31 to 46%, at 80°C, and in 10 to 25 hours of reaction.
The effect of the five fluoroquinolone-boron hybrids was evaluated in cervical cancer cell lines by cell proliferation assay.
7-hydantoin-fluoroquinolone-boron and 7-dihydropyridine-fluoroquinolone-boron complexes showed the strongest effect according to dose-response assay, respectively.
The fluoroquinolone-boron hybrid complex showed proliferation inhibition in SiHa and CasKi cells, opening the possibility to use them as potential agents for the treatment of cancer.
American Psychological Association (APA)
Hernández-López, Hiram& Sánchez-Miranda, Griselda& Araujo-Huitrado, Jorge Gustavo& Granados-López, Angelica Judith& Lopez, Jesús Adrián& Leyva-Ramos, Socorro…[et al.]. 2019. Synthesis of Hybrid Fluoroquinolone-Boron Complexes and Their Evaluation in Cervical Cancer Cell Lines. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1171278
Modern Language Association (MLA)
Hernández-López, Hiram…[et al.]. Synthesis of Hybrid Fluoroquinolone-Boron Complexes and Their Evaluation in Cervical Cancer Cell Lines. Journal of Chemistry No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1171278
American Medical Association (AMA)
Hernández-López, Hiram& Sánchez-Miranda, Griselda& Araujo-Huitrado, Jorge Gustavo& Granados-López, Angelica Judith& Lopez, Jesús Adrián& Leyva-Ramos, Socorro…[et al.]. Synthesis of Hybrid Fluoroquinolone-Boron Complexes and Their Evaluation in Cervical Cancer Cell Lines. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1171278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171278