![](/images/graphics-bg.png)
Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels
Joint Authors
Chen, Qin-Fen
Cao, Dan
Ye, Ting-Ting
Deng, Hui-Hui
Zhu, Hong
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography.
Methods.
We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females).
The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly.
Furthermore, the univariate and multiple logistic analyses were performed to explore the correlation between PAD and fibrinogen levels, individual components in the cross-sectional study.
Results.
Finally, 887 (80.9%) T2DM patients meet the diagnostic criteria of PAD and these patients had considerably higher serum fibrinogen concentration than non-PAD group (P<0.001).
Multiple logistic analyses revealed that higher fibrinogen quartiles were positively related with the development of PAD in the adjusted model.
After adjusting for known confounding parameters, the ORs for PAD were 1.993 (95% CI: 1.322-3.005, P<0.001), 2.469 (95% CI: 1.591-3.831, P<0.001), and 2.942 (95% CI, 1.838-4.711, P<0.001) for Q2, Q3, and Q4, respectively (all P values <0.05).
Conclusions.
Our results suggest that serum fibrinogen concentration can be considered as an independent risk factor for PAD in T2DM patients.
American Psychological Association (APA)
Chen, Qin-Fen& Cao, Dan& Ye, Ting-Ting& Deng, Hui-Hui& Zhu, Hong. 2018. Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171281
Modern Language Association (MLA)
Chen, Qin-Fen…[et al.]. Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1171281
American Medical Association (AMA)
Chen, Qin-Fen& Cao, Dan& Ye, Ting-Ting& Deng, Hui-Hui& Zhu, Hong. Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171281