MicroRNA Biomarker hsa-miR-195-5p for Detecting the Risk of Lung Cancer
Joint Authors
Yu, Herbert
Feng, Tienan
Li, Lei
Zhang, Weituo
Gao, Sumeng
Wang, Ruoyang
Lv, Wenwen
Zhu, Tengteng
Qian, Biyun
Source
International Journal of Genomics
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Lung cancer is one of the leading diagnosed cancers worldwide, and microRNAs could be used as biomarkers to diagnose lung cancer.
hsa-miR-195 has been demonstrated to affect the prognosis of NSCLC (non-small-cell lung cancer) in a previous study.
However, the diagnostic value of hsa-miR-195-5p in lung cancer has not been investigated.
Methods.
To evaluate the ability of hsa-miR-195-5p to diagnose lung cancer, we compared the expression of hsa-miR-195-5p in lung cancer patients, COPD patients, and normal controls.
Receiver operating characteristic (ROC) curve analysis was performed to investigate the sensitivity and specificity of hsa-miR-195-5p.
Coexpression network and pathway analysis were carried out to explore the mechanism.
Results.
We found that hsa-miR-195-5p had lower expression in lung cancer and COPD patients than in normal controls, and the AUC was 0.92 for diagnosing lung cancer.
hsa-miR-143 correlated with hsa-miR-195-5p, and by combining these two microRNAs, the AUC was 0.97 for diagnosing lung cancer.
Conclusions.
hsa-miR-195-5p may act as a biomarker that contributes to the diagnosis of lung cancer and the detection of its high-risk population.
American Psychological Association (APA)
Li, Lei& Feng, Tienan& Zhang, Weituo& Gao, Sumeng& Wang, Ruoyang& Lv, Wenwen…[et al.]. 2020. MicroRNA Biomarker hsa-miR-195-5p for Detecting the Risk of Lung Cancer. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1171307
Modern Language Association (MLA)
Li, Lei…[et al.]. MicroRNA Biomarker hsa-miR-195-5p for Detecting the Risk of Lung Cancer. International Journal of Genomics No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1171307
American Medical Association (AMA)
Li, Lei& Feng, Tienan& Zhang, Weituo& Gao, Sumeng& Wang, Ruoyang& Lv, Wenwen…[et al.]. MicroRNA Biomarker hsa-miR-195-5p for Detecting the Risk of Lung Cancer. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1171307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171307