Downregulation of miR-1826 Indicates a Poor Prognosis for Osteosarcoma Patients and Regulates Tumor Cell Proliferation, Migration, and Invasion
Joint Authors
Source
International Journal of Genomics
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Osteosarcoma (OS) is the most frequent bone tumor with high metastasis.
This study is aimed at assessing the expression and prognostic significance of microRNA-1826 (miR-1826) in OS patients, as well as its biological function in tumor progression.
Methods.
Quantitative Real-Time PCR was employed to measure the expression of miR-1826 in OS tissues and cell lines.
Kaplan-Meier survival analysis and Cox regression model were used to evaluate the prognostic value of miR-1826.
CCK-8 and Transwell assay were conducted to investigate the effect of miR-1826 on OS cell proliferation, migration, and invasion.
Results.
miR-1826 expression was downregulated in OS tissues and cell lines and associated with OS patients’ clinical stage and distant metastasis.
Low levels of miR-1826 were related with shorter survival time and determined as an independent prognostic indicator for the overall survival of OS patients.
The overexpression of miR-1826 in OS cells led to inhibited cell proliferation, migration, and invasion.
Conclusion.
The decreased expression of miR-1826 predicts a poor prognosis in OS patients, and its overexpression inhibits OS cell proliferation, migration, and invasion.
This newly identified miR-1826 provides a novel sight into the pathogenesis of OS and offers a candidate prognostic biomarker and therapeutic target for OS treatment.
American Psychological Association (APA)
Li, Peng& Wei, Lei& Zhu, Wenshuai. 2020. Downregulation of miR-1826 Indicates a Poor Prognosis for Osteosarcoma Patients and Regulates Tumor Cell Proliferation, Migration, and Invasion. International Journal of Genomics،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171328
Modern Language Association (MLA)
Li, Peng…[et al.]. Downregulation of miR-1826 Indicates a Poor Prognosis for Osteosarcoma Patients and Regulates Tumor Cell Proliferation, Migration, and Invasion. International Journal of Genomics No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1171328
American Medical Association (AMA)
Li, Peng& Wei, Lei& Zhu, Wenshuai. Downregulation of miR-1826 Indicates a Poor Prognosis for Osteosarcoma Patients and Regulates Tumor Cell Proliferation, Migration, and Invasion. International Journal of Genomics. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171328