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Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases
Joint Authors
Tetta, Ciro
Pomatto, Margherita A. C.
Gai, Chiara
Deregibus, Maria Chiara
Camussi, Giovanni
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
RNA molecules are essential and fine regulators of important biological processes.
Their role is well documented also in the endocrine system, both in physiological and pathological conditions.
Increasing interest is arising about the function and the importance of noncoding RNAs shuttled by extracellular vesicles (EVs).
In fact, EV membrane protects nucleic acids from enzyme degradation.
Nowadays, the research on EVs and their cargoes, as well as their biological functions, faces the lack of standardization in EV purification.
Here, the main techniques for EV isolation are discussed and compared for their advantages and vulnerabilities.
Despite the possible discrepancy due to methodological variability, EVs and their RNA content are reported to be key mediators of intercellular communication in pathologies of main endocrine organs, including the pancreas, thyroid, and reproductive system.
In particular, the present work describes the role of RNAs contained in EVs in pathogenesis and progression of several metabolic dysfunctions, including obesity and diabetes, and their related manifestations.
Their importance in the establishment and progression of thyroid autoimmunity disorders and complicated pregnancy is also discussed.
Preliminary studies highlight the attractive possibility to use RNAs contained in EVs as biomarkers suggesting their exploitation for new diagnostic approaches in endocrinology.
American Psychological Association (APA)
Pomatto, Margherita A. C.& Gai, Chiara& Deregibus, Maria Chiara& Tetta, Ciro& Camussi, Giovanni. 2018. Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1171384
Modern Language Association (MLA)
Pomatto, Margherita A. C.…[et al.]. Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases. International Journal of Endocrinology No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1171384
American Medical Association (AMA)
Pomatto, Margherita A. C.& Gai, Chiara& Deregibus, Maria Chiara& Tetta, Ciro& Camussi, Giovanni. Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1171384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171384