![](/images/graphics-bg.png)
PI3K Inhibitors of Novel Hydrazide Analogues Linked 2-Pyridinyl Quinazolone Scaffold as Anticancer Agents
Joint Authors
Khalifa, Nagy M.
Zeid, Ibrahim F.
Mohamed, Neama A.
Kassem, Emad M.
Nossier, Eman S.
Salman, Ahmed A.
Mahmoud, Khaled
al-Omar, Mohamed A.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A series of novel 2-(pyridin-4-yl)quinazolin-4(3H)-ones bearing different heterocycle cores as potential PI3K inhibitors have been synthesized and evaluated via the MTT assay for their antiproliferative properties against selected HePG-2, MCF-7, and HCT116 cancer cell lines.
Among them, compound 9 displayed significant activity against HePG-2 (IC50 = 60.29 ± 1.06 μM) comparable to doxorubicin as a reference anticancer drug (IC50 = 69.60 ± 1.50 μM).
Kinase inhibitory assessment of target products against PI3K and docking studies revealed the promising binding affinities which match with the binding mode of the ligand, SW13 towards the active site of PI3K.
Therefore, this work represents a promising matrix for developing novel potential anticancer candidates.
American Psychological Association (APA)
Zeid, Ibrahim F.& Mohamed, Neama A.& Khalifa, Nagy M.& Kassem, Emad M.& Nossier, Eman S.& Salman, Ahmed A.…[et al.]. 2019. PI3K Inhibitors of Novel Hydrazide Analogues Linked 2-Pyridinyl Quinazolone Scaffold as Anticancer Agents. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1171385
Modern Language Association (MLA)
Zeid, Ibrahim F.…[et al.]. PI3K Inhibitors of Novel Hydrazide Analogues Linked 2-Pyridinyl Quinazolone Scaffold as Anticancer Agents. Journal of Chemistry No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1171385
American Medical Association (AMA)
Zeid, Ibrahim F.& Mohamed, Neama A.& Khalifa, Nagy M.& Kassem, Emad M.& Nossier, Eman S.& Salman, Ahmed A.…[et al.]. PI3K Inhibitors of Novel Hydrazide Analogues Linked 2-Pyridinyl Quinazolone Scaffold as Anticancer Agents. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1171385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171385