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Role of Lipotoxicity and Contribution of the Renin-Angiotensin System in the Development of Polycystic Ovary Syndrome
Joint Authors
Connolly, Alexandre
Leblanc, Samuel
Baillargeon, Jean-Patrice
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Polycystic ovary syndrome (PCOS) is a common and significant condition associated with hyperandrogenism, infertility, low quality of life, and metabolic comorbidities.
One possible explanation of PCOS development is cellular dysfunction induced by nonesterified fatty acids (NEFAs), that is, lipotoxicity, which could explain both the hyperandrogenemia and insulin resistance that characterize women with PCOS.
The literature suggests that androgen biosynthesis may be induced by overexposure of androgen-secreting tissues to NEFA and/or defective NEFA metabolism, leading to lipotoxic effects.
Indeed, lipotoxicity could trigger androgenic hyperresponsiveness to insulin, LH, and ACTH.
In most PCOS women, lipotoxicity also causes insulin resistance, inducing compensatory hyperinsulinemia, and may thus further increase hyperandrogenemia.
Many approaches aimed at insulin sensitization also reduce lipotoxicity and have been shown to treat PCOS hyperandrogenemia.
Furthermore, our group and others found that angiotensin II type 2 receptor (AT2R) activation is able to improve lipotoxicity.
We provided evidence, using C21/M24, that AT2R activation improves adipocytes’ size and insulin sensitivity in an insulin-resistant rat model, as well as androgen levels in a PCOS obese rat model.
Taken together, these findings point toward the important role of lipotoxicity in PCOS development and of the RAS system as a new target for the treatment of PCOS.
American Psychological Association (APA)
Connolly, Alexandre& Leblanc, Samuel& Baillargeon, Jean-Patrice. 2018. Role of Lipotoxicity and Contribution of the Renin-Angiotensin System in the Development of Polycystic Ovary Syndrome. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1171386
Modern Language Association (MLA)
Connolly, Alexandre…[et al.]. Role of Lipotoxicity and Contribution of the Renin-Angiotensin System in the Development of Polycystic Ovary Syndrome. International Journal of Endocrinology No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1171386
American Medical Association (AMA)
Connolly, Alexandre& Leblanc, Samuel& Baillargeon, Jean-Patrice. Role of Lipotoxicity and Contribution of the Renin-Angiotensin System in the Development of Polycystic Ovary Syndrome. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1171386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171386