Endothelial Dysfunction, a Marker of Atherosclerosis, Is Independent of Metabolic Syndrome in NAFLD Patients
Joint Authors
Narayan, Jimmy
Das, Haribhakti Seba
Nath, Preetam
Singh, Ayaskanta
Mishra, Debakanta
Padhi, Pradeep Kumar
Singh, Shivaram Prasad
Source
International Journal of Hepatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The study was designed to assess cardiovascular risk factors flow-mediated dilatation % (FMD%) and carotid intima-media thickness (CIMT) in NAFLD.
Methods.
126 NAFLD subjects and 31 chronic hepatitis B (CHB) controls were studied.
Measuring carotid intima-media thickness (CIMT) and the flow-mediated dilatation % (FMD%) by brachial artery Doppler ultrasound were used to assess atherosclerosis.
The risk of cardiac events at 10 years (ROCE 10) was estimated by the Prospective Cardiovascular Munster Study (PROCAM) score.
Results.
58 of 126 NAFLD have coexistent metabolic syndrome.
Mean CIMT was 0.73±0.041 mm among NAFLD with MS, 0.66±0.016 mm among NAFLD without MS, and 0.66±0.037 in controls CHB patients.
FMD% in NAFLD with MS was 10.43±3.134%, but was 8.56±3.581% in NAFLD without MS and 17.78±6.051% in controls.
PROCAM score of NAFLD with MS was 46.95±6.509 while in NAFLD without MS was 38.2±3.738.
Controls had a PROCAM score of 38.13±5.755.
ROCE 10 in NAFLD with MS was 13.64±8.568 while NAFLD without MS was 5.55±1.949.
Controls have a ROCE 10 of 5.95±3.973.
Post hoc analysis showed CIMT was dependent upon MS while FMD% was different between all subgroups hence independent of metabolic syndrome.
Conclusion.
The markers of endothelial dysfunction are significantly higher in patients with NAFLD than controls.
American Psychological Association (APA)
Narayan, Jimmy& Das, Haribhakti Seba& Nath, Preetam& Singh, Ayaskanta& Mishra, Debakanta& Padhi, Pradeep Kumar…[et al.]. 2020. Endothelial Dysfunction, a Marker of Atherosclerosis, Is Independent of Metabolic Syndrome in NAFLD Patients. International Journal of Hepatology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171428
Modern Language Association (MLA)
Narayan, Jimmy…[et al.]. Endothelial Dysfunction, a Marker of Atherosclerosis, Is Independent of Metabolic Syndrome in NAFLD Patients. International Journal of Hepatology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1171428
American Medical Association (AMA)
Narayan, Jimmy& Das, Haribhakti Seba& Nath, Preetam& Singh, Ayaskanta& Mishra, Debakanta& Padhi, Pradeep Kumar…[et al.]. Endothelial Dysfunction, a Marker of Atherosclerosis, Is Independent of Metabolic Syndrome in NAFLD Patients. International Journal of Hepatology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1171428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171428