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Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis
Joint Authors
Mathiesen, Inger Hee
Pressler, Tacjana
Oturai, Peter
Katzenstein, Terese Lea
Skov, Marianne
Frikke-Schmidt, Ruth
Hitz, Mette Friberg
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Cystic fibrosis (CF) patients are in increased risk of osteoporosis.
We aimed to determine the osteoporosis prevalence in an adult CF cohort and investigate calcium metabolic parameters and clinical status’ association with bone mineral density evaluated by dual X-ray absorptiometry scan.
Methods.
We performed a cross section database study of adults at a tertiary CF Center.
Z scores were applied for patients < 50 years of age and T scores for patients > 50 years of age.
Results.
One hundred twenty-five patients were included.
Compared to nonosteoporotic patients, osteoporotic patients (15%) had significantly lower percent predicted forced expiratory volume in 1 second (ppFEV1), lower body mass index, higher frequency of CF-related diabetes and chronic lung infection, and higher high-sensitive C-reactive protein and glycated hemoglobin levels.
Vitamin D was not associated with any outcome.
In multivariate analyses, only ppFEV1 and female gender were independently associated with Z scores.
Conclusions.
Osteoporosis in CF occurs with deteriorating clinical status while the role of calcium metabolism seems minor.
Gender specific and dysglycemic impact on bone status should be investigated further.
American Psychological Association (APA)
Mathiesen, Inger Hee& Pressler, Tacjana& Oturai, Peter& Katzenstein, Terese Lea& Skov, Marianne& Frikke-Schmidt, Ruth…[et al.]. 2018. Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171457
Modern Language Association (MLA)
Mathiesen, Inger Hee…[et al.]. Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis. International Journal of Endocrinology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1171457
American Medical Association (AMA)
Mathiesen, Inger Hee& Pressler, Tacjana& Oturai, Peter& Katzenstein, Terese Lea& Skov, Marianne& Frikke-Schmidt, Ruth…[et al.]. Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1171457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171457