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Diagnostic Values of Free Triiodothyronine and Free Thyroxine and the Ratio of Free Triiodothyronine to Free Thyroxine in Thyrotoxicosis
Joint Authors
Zhou, Yulin
Yin, Qinglei
Chen, Xinxin
Zhou, Mengxi
Wang, Shu
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The results of previous studies on the usefulness of free triiodothyronine (FT3) to free thyroxine (FT4) are controversial.
We investigated the usefulness of FT3, FT4, and FT3/FT4 ratio in differentiating Graves’ disease (GD) from destructive thyroiditis.
Methods.
A total of 126 patients with untreated GD, 36 with painless thyroiditis, 18 with painful subacute thyroiditis, and 63 healthy controls, were recruited.
The levels of FT3 and FT4 and the FT3/FT4 ratios for the different etiologies of thyrotoxicosis were evaluated separately by receiver operating characteristic (ROC) curve analysis.
The expression levels of type 1 and type 2 deiodinase (DIO1 and DIO2) in thyroid tissues were also investigated.
Results.
The optimal cut-off values were 7.215 pmol/L for FT3, 21.71 pmol/L for FT4, and 0.4056 for the FT3/FT4 ratio.
The specificity and positive predictive value of the FT3/FT4 ratio were highest for values > 0.4056.
DIO1 mRNA expression was significantly higher in the thyroid tissue of patients with GD (P=0.013).
Conclusions.
We demonstrated that the FT3/FT4 ratio was useful in differentiating GD from destructive thyroiditis.
In addition, a relatively high expression of type 1 deiodinase in the thyroid might be responsible for the high FT3/FT4 ratio in patients with GD.
American Psychological Association (APA)
Chen, Xinxin& Zhou, Yulin& Zhou, Mengxi& Yin, Qinglei& Wang, Shu. 2018. Diagnostic Values of Free Triiodothyronine and Free Thyroxine and the Ratio of Free Triiodothyronine to Free Thyroxine in Thyrotoxicosis. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171460
Modern Language Association (MLA)
Chen, Xinxin…[et al.]. Diagnostic Values of Free Triiodothyronine and Free Thyroxine and the Ratio of Free Triiodothyronine to Free Thyroxine in Thyrotoxicosis. International Journal of Endocrinology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1171460
American Medical Association (AMA)
Chen, Xinxin& Zhou, Yulin& Zhou, Mengxi& Yin, Qinglei& Wang, Shu. Diagnostic Values of Free Triiodothyronine and Free Thyroxine and the Ratio of Free Triiodothyronine to Free Thyroxine in Thyrotoxicosis. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1171460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171460