Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice
Joint Authors
Danish, Lubna
Siddiq, Riffat
Jahan, Sarwat
Taneez, Mehwish
Khan, Manzoor
Sandhu, Marva
Source
International Journal of Hepatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential.
Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis.
The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol.
In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both.
The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil.
Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity.
American Psychological Association (APA)
Danish, Lubna& Siddiq, Riffat& Jahan, Sarwat& Taneez, Mehwish& Khan, Manzoor& Sandhu, Marva. 2020. Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice. International Journal of Hepatology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1171469
Modern Language Association (MLA)
Danish, Lubna…[et al.]. Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice. International Journal of Hepatology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1171469
American Medical Association (AMA)
Danish, Lubna& Siddiq, Riffat& Jahan, Sarwat& Taneez, Mehwish& Khan, Manzoor& Sandhu, Marva. Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice. International Journal of Hepatology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1171469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171469