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Biological and Clinical Effects of Calciprotein Particles on Chronic Kidney Disease-Mineral and Bone Disorder
Joint Authors
Shiizaki, Kazuhiro
Kimura, Takaaki
Akiyama, Kenichi
Source
International Journal of Endocrinology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Calciprotein particles (CPPs) are a new biological marker of chronic kidney disease-mineral and bone disorder (CKD-MBD).
CPPs consist of phosphate, calcium, and some proteins, with phosphate being the major contributor to the level and biological activity of CPPs.
Recent studies have shown the physiological and pathological significance of CPPs, including contributions to bone and mineral metabolism, and to tissue and organ impairments such as cardiovascular damage and inflammatory responses.
These actions are well known as important aspects of CKD-MBD.
Fibroblast growth factor 23 (FGF23), which is secreted from the bone as the phosphaturic hormone, is markedly elevated in CKD-MBD.
Many clinical studies have shown significant relationships between the level of FGF23 and outcomes such as mortality, prevalence of cardiovascular disease, bone fracture, and levels of inflammatory markers.
Basic and clinical studies have suggested that CPPs contribute to synthesis and secretion of FGF23.
Surgical treatments such as renal transplantation and parathyroidectomy for patients with CKD-MBD suppress excess levels of phosphate, calcium, parathyroid hormone (PTH), and FGF23, which are related to the CPP level.
Therefore, suppression of CPPs might also contribute to improved clinical outcomes after these treatments.
American Psychological Association (APA)
Akiyama, Kenichi& Kimura, Takaaki& Shiizaki, Kazuhiro. 2018. Biological and Clinical Effects of Calciprotein Particles on Chronic Kidney Disease-Mineral and Bone Disorder. International Journal of Endocrinology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1171516
Modern Language Association (MLA)
Akiyama, Kenichi…[et al.]. Biological and Clinical Effects of Calciprotein Particles on Chronic Kidney Disease-Mineral and Bone Disorder. International Journal of Endocrinology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1171516
American Medical Association (AMA)
Akiyama, Kenichi& Kimura, Takaaki& Shiizaki, Kazuhiro. Biological and Clinical Effects of Calciprotein Particles on Chronic Kidney Disease-Mineral and Bone Disorder. International Journal of Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1171516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171516