Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes
Joint Authors
Tirkeso, Radiet Anbessie
Tsega, Tilahun Wubalem
Amdemichael, Gebru G/Tsadik
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
As multidrug resistant pathogens are emerging, the search for novel potent drug candidates is ever going.
Heterocycles are known by their broad spectrum of biological activities, so a search for a new drug from heterocycles can elevate the chance of success.
The aim of this study was to obtain novel potent antimicrobial compounds.
In line with this, 1H-imidazo [5, 6-f] [1,10] phenanthroline-2(3H)-thione and its complexes (Ni(II) and Cu(II)) were synthesized, characterized, and evaluated against bacterial strains.
The compounds were characterized by elemental analyses (C, H, N, and S), FT-IR, 1H-NMR, 13C-NMR, AAS, UV-Vis spectra, and molar conductivity measurement.
The results showed that the ligand is bidentate, and the molar conductivity measurement indicates that complexes are electrolytic.
Electronic spectral study showed octahedral and distorted octahedral geometry for the Ni(II) and Cu(II) complex, respectively.
The ligand and its complexes were screened against four bacterial strains using disk diffusion method.
The result revealed that the Ni(II) complex showed more bioactivity than gentamicin against Staphylococcus aureus and Escherichia coli, while the Cu(II) complex is more active than the Ni(II) complex against Bacillus subtilis.
Both Cu(II) and Ni(II) complexes exhibit higher antibacterial activities than the free ligand.
American Psychological Association (APA)
Tirkeso, Radiet Anbessie& Tsega, Tilahun Wubalem& Amdemichael, Gebru G/Tsadik. 2019. Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes. Journal of Chemistry،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1171530
Modern Language Association (MLA)
Tirkeso, Radiet Anbessie…[et al.]. Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes. Journal of Chemistry No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1171530
American Medical Association (AMA)
Tirkeso, Radiet Anbessie& Tsega, Tilahun Wubalem& Amdemichael, Gebru G/Tsadik. Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes. Journal of Chemistry. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1171530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171530