Association of Lactate Dehydrogenase with In-Hospital Mortality in Patients with Acute Aortic Dissection: A Retrospective Observational Study
Joint Authors
Yang, Guifang
He, Huaping
Pan, Xiaogao
Chai, Xiangping
Zhou, Yang
Source
International Journal of Hypertension
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Evidence regarding the relationship between serum lactate dehydrogenase (LDH) levels and in-hospital mortality in acute aortic dissection (AAD) patients is extremely limited.
We aimed to investigate the relationship between LDH and in-hospital mortality in AAD patients.
Methods.
The present study was a retrospective observational study.
A total of 1526 participants with acute aortic dissection were involved in a hospital in China from January 2014 to December 2018.
The target-independent variable was LDH measured at baseline, and the dependent was all-cause mortality during hospitalization.
Covariates involved in this study included age, gender, body mass index (BMI), hypertension, diabetes, smoking, stroke, atherosclerosis, systolic blood pressure (SBP), diastolic blood pressure (DBP), white blood cell (WBC), hemoglobin (Hb), alanine transaminase (ALT), aspartate aminotransferase (AST), albumin (ALB), creatinine (Cr), symptom, type of AAD (Stanford), and management.
Results.
The average age of 1526 selected participants was 52.72 ± 11.94 years old, and about 80.41% of them were male.
The result of the fully adjusted model showed LDH was positively associated with in-hospital mortality in AAD patients after adjusting confounders (OR = 1.09, 95% CI 1.05 to 1.13).
A nonlinear relationship was detected between LDH and in-hospital mortality in AAD patients after adjusting for potential confounders (age, gender, BMI, hypertension, diabetes, stroke, atherosclerosis, smoking, symptom, SBP, DBP, WBC, Hb, ALT, AST, ALB, Cr, type of AAD (Stanford), and management), whose point was 557.
The effect sizes and the confidence intervals of the left and right sides of the inflection point were 0.90 (0.74–1.10) and 1.12 (1.06–1.19), respectively.
Subgroup analysis in participants showed that the relationship between LDH and in-hospital mortality was stable, and all of the P value for the interaction in different subgroup were more than 0.05.
Conclusions.
The relationship between LDH and in-hospital mortality in AAD patients is nonlinear.
LDH was positively related with in-hospital mortality when LDH is more than 557.
American Psychological Association (APA)
He, Huaping& Chai, Xiangping& Zhou, Yang& Pan, Xiaogao& Yang, Guifang. 2020. Association of Lactate Dehydrogenase with In-Hospital Mortality in Patients with Acute Aortic Dissection: A Retrospective Observational Study. International Journal of Hypertension،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1171531
Modern Language Association (MLA)
He, Huaping…[et al.]. Association of Lactate Dehydrogenase with In-Hospital Mortality in Patients with Acute Aortic Dissection: A Retrospective Observational Study. International Journal of Hypertension No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1171531
American Medical Association (AMA)
He, Huaping& Chai, Xiangping& Zhou, Yang& Pan, Xiaogao& Yang, Guifang. Association of Lactate Dehydrogenase with In-Hospital Mortality in Patients with Acute Aortic Dissection: A Retrospective Observational Study. International Journal of Hypertension. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1171531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171531