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Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents
Joint Authors
Hussain, Mohd Hasnain Md.
Abd Halim, Ainaa Nadiah
Ngaini, Zainab
Nordin, Norsyafikah Asyilla
Chai, Tchan Wei
Tan, Bee Ling
Choi, Ching Liang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A new series of aspirin bearing alkylated amines moieties 1–12 were synthesised by reacting isothiocyanate with a series of aniline derivatives in overall yield of 16–56%.
The proposed structures of all the synthesised compounds were confirmed using elemental analysis, FTIR, and 1H and 13C NMR spectroscopy.
All compounds were evaluated for antibacterial activities against E.
coli and S.
aureus via turbidimetric kinetic and Kirby Bauer disc diffusion method.
Compound 5 bearing meta -CH3 substituent showed the highest relative inhibition zone diameter against tested bacteria compared to ortho and para substituent.
Furthermore, aspirin derivatives bearing shorter chains exhibited better bacterial inhibition than longer alkyl chains.
American Psychological Association (APA)
Nordin, Norsyafikah Asyilla& Chai, Tchan Wei& Tan, Bee Ling& Choi, Ching Liang& Abd Halim, Ainaa Nadiah& Hussain, Mohd Hasnain Md.…[et al.]. 2017. Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents. Journal of Chemistry،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1171538
Modern Language Association (MLA)
Nordin, Norsyafikah Asyilla…[et al.]. Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents. Journal of Chemistry No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1171538
American Medical Association (AMA)
Nordin, Norsyafikah Asyilla& Chai, Tchan Wei& Tan, Bee Ling& Choi, Ching Liang& Abd Halim, Ainaa Nadiah& Hussain, Mohd Hasnain Md.…[et al.]. Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents. Journal of Chemistry. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1171538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1171538